Introduction:The diagnosis of cutaneous lymphomas is extremely difficult because of their morphological diversity and clinical similarity to many dermatoses. Objective: Presentation of the case of a 70-year-old woman diagnosed with lichen sclerosus in whom the evolution of skin lesions raised suspicions of lymphocytic hyperplasia. Case report: The patient diagnosed with lichen sclerosus was hospitalized three times due to exacerbation of skin lesions with accompanying mycosis fungoides-mimicking infiltration. Cutaneous lymphoma was excluded in biopsy specimens collected from skin lesions. In the following months, a new nodular lesion appeared on the patient's face that turned out to be marginal zone lymphoma. After increasing the dose of methotrexate to 20 mg/week, a rapid remission of skin lesions was achieved. Conclusions: The presented case shows that the diagnosis of primary cutaneous lymphoma is a significant challenge in everyday dermatological practice and requires repeated biopsy.streszczenie Wprowadzenie: Diagnostyka chłoniaków skóry jest niezwykle trudna ze względu na ich zróżnicowanie morfologiczne i kliniczne podobieństwo do wielu dermatoz. Cel pracy: Przedstawienie przypadku 70-letniej pacjentki z rozpoznanym liszajem twardzinowym, u której ewolucja zmian skórnych budziła podejrzenie rozrostu limfocytarnego. Opis przypadku: Pacjentkę z rozpoznanym liszajem twardzinowym hospitalizowano trzykrotnie z powodu zaostrzenia zmian skórnych z towarzyszącym naciekiem imitujących ziarniniaka grzybiastego. W pobranych wycinkach ze zmian skórnych wykluczono diagnozę chłoniaka skóry. W kolejnych miesiącach doszło do pojawienia się nowej guzowatej zmiany na twarzy, która okazała się chłoniakiem strefy
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