In this paper, we present a literature review of the role of CXC motif chemokine ligand 1 (CXCL1) in physiology, and in selected major non-cancer diseases of the cardiovascular system, respiratory system and skin. CXCL1, a cytokine belonging to the CXC sub-family of chemokines with CXC motif chemokine receptor 2 (CXCR2) as its main receptor, causes the migration and infiltration of neutrophils to the sites of high expression. This implicates CXCL1 in many adverse conditions associated with inflammation and the accumulation of neutrophils. The aim of this study was to describe the significance of CXCL1 in selected diseases of the cardiovascular system (atherosclerosis, atrial fibrillation, chronic ischemic heart disease, hypertension, sepsis including sepsis-associated encephalopathy and sepsis-associated acute kidney injury), the respiratory system (asthma, chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis, coronavirus disease 2019 (COVID-19), influenza, lung transplantation and ischemic-reperfusion injury and tuberculosis) and the skin (wound healing, psoriasis, sunburn and xeroderma pigmentosum). Additionally, the significance of CXCL1 is described in vascular physiology, such as the effects of CXCL1 on angiogenesis and arteriogenesis.
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Phantom pain (PhP)is reported by patients after limb amputation due to trauma or chronic diseases. We report the case of successful PhP treatment with pulsed radiofrequency (PRF) of the femoral and sciatic nerve. (PRF) reduced the intensity of pain for one year, improving the quality of life of the patient.
Introduction: The knee joint is one of the most commonly injured joints, especially among physically active persons. In turn, the anterior cruciate ligament (ACL) is the knee ligament which is most frequently torn. Water treadmill therapy is one of the forms of rehabilitation available for patients after ACL reconstruction. Materials and Method: The case of a 38-year-old woman is presented who during parachute jumping sustained injury to the knee joint on landing. Using the magnetic resonance imaging (MRI) a tear of the ACL was diagnosed. Physiotherapeutic examination was performed: palpation and visual observation of both knee joints: assessment of position of the patella and the axes of the lower limbs, assessment of joint temperature, patella ballottement sign, and tenderness. In order to objectively monitor the progress of therapy measurements were taken of the circumference of the lower limbs, and pain complains assessed according to the VAS scale. Eight weeks after reconstruction of the anterior cruciate ligament, the patient underwent 30 treadmill therapy treatments. Results: Quadriceps muscle mass gain and reduction of the knee joint swelling were observed. Full range of knee joint motion was confirmed, and lack of pain in the medial compartment of the knee joint. Conclusions: Water treadmill therapy is an effective supplementation of the process of patient rehabilitation after reconstruction of the anterior cruciate ligament.
Introduction: Devic’s syndrome also known as neuromyelitis optica is an autoimmune disease of central nervous system (CNS).It has an inflammatory, demyelizatory, chronic and relapsing nature, where ones own immune system attacks the spinal cord and optic nerves. Material and Methods: The authors presented a case report of a 54-year-old woman diagnosed with Devic’s syndrome 2 years ago. The physiotherapeutic examination revealed: visual and balance disturbances, decrease in muscle strength of upper and lower limbs, unsteady and shaky gait with a need to use a zimmer frame. At the start and at the end of a therapy, to objectively monitor the progress of rehabilitation treatment, a number of functional tests were used that included: Barthel Index, Brunnstrom’s test, Rankin Scale, Ashworth’s scale, Lovett’s test and a timed 20m walk. In physiotherapeutic treatment process patterns and techniques of PNF (prioprioceptive neuromuscular facilitation) ware used as well as exercise to correct muscles tone and strengthening exercise of trunk and lower limbs. Results: As a result of applying a comprehensive rehabilitation approach an increase of muscles strength of upper and lower limbs was obtained (Lovett’s scale R/L: shoulder 5/5, elbow 5/5, hand 5/5, hip 4+/4+, knee 4+/4+, foot 4+/4+). In addition all postural muscles gained in strength and an improvement in hands dexterity, body coordination and balance was noticed. Conclusion: Multidisciplinary approach and an individually selected rehabilitation program proves to show beneficial effects in a treatment process of patients with Devic’s syndrome.
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