The hybrid peptides consisting of α and β-amino acids show great promise as peptidomimetics that can be used as therapeutic agents. Therefore, the development of new unnatural amino acids and the methods of their incorporation into the peptide chain is an important task. Here, we described our investigation of the possibility of 5-amino-3-methyl-isoxazole-4-carboxylic acid (AMIA) application in the solid phase peptide synthesis. This new unnatural β-amino acid, presenting various biological activities, was successfully coupled to a resin-bound peptide using different reaction conditions, including classical and ultrasonic agitated solid-phase synthesis. All the synthesized compounds were characterized by tandem mass spectrometry. The obtained results present the possibility of the application of this β-amino acid in the synthesis of a new class of bioactive peptides.
With the rapid development of information technology, many aspects of our lives are undergoing a digital transformation. An increasing number of users are going online every year, and constantly improving artificial intelligence is gaining popularity, which leads to the growing production of information. Nowadays, information is usually stored in data centres, which will be forced to increase their space with the constant flow of new bits of information. Together with the increase in their space, energy consumption and associated maintenance costs are escalating. In 2021, global data centre power consumption was 220–320 TWh, which is about 0.9–1.3% of global power consumption. Continuous power supply for database operations is responsible for about 1% of total carbon dioxide emissions. Furthermore, it has already been reported that with the exponentially growing amount of data, in about 20 years, the amount of silicon for microprocessors will no longer be sufficient to store all the information. Therefore, scientists are looking for alternatives to the currently used data storage solutions and are developing new technologies using chemical molecules. Recently, even plastic has been explored as a data carrier. In this work, we present examples of new technologies for data storage in polymers. We have discussed polymers as data carriers in comparison with currently used solutions and deliberated whether plastic can become a future material for information archiving.
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