BACKGROUND:44 Sc as a positron emitter can be an interesting alternative to 68 Ga (T ½ = 67.71 min) due to its longer half-life (T ½ = 3.97 h). Moreover, the b -emitter 47

SummaryThe purpose of this study was to investigate radiochemical and biological characteristics of an instant kit for the preparation of TcO 4 À to the kit ITLC and HPLC reversephase analysis was performed. Stability of the labelled complex was challenged and the binding to bacterial pellets was assessed. Finally, the biodistribution and accumulation in MRSA-infected tissues were studied using scintigraphy and ex vivo countings. Data were compared to a non-kit control method.Radiochemical analysis indicated >96% labelling, stability for 24 h and the preparation was used without purification. In vitro studies showed 41% of radioactivity was bound to bacteria. After injection into mice with a bacterial infection the site of infection was visualized within 30 min. Kit prepared