Background: Vaginal agenesis is a rare condition, therefore
the incidence of a malignant transformation in the
neovagina is extremely low. Case Report: We report on a
42-year-old patient with Morris’ syndrome and urinary
bladder neovagina with a history of prolonged infections
of the urinary bladder and intertrigo of the perineal region.
The biopsy revealed a squamous cell carcinoma
arising from the neovagina. The patient underwent combined
radio- and chemotherapy and was disqualified
from surgical treatment because of the advanced stage
of the disease. Conclusions: Because of the high risk of
malignant transformations regular follow-ups are necessary
in patients with neovagina creation, including gynecological
examination, cytological screening, and biopsy
if necessary. In addition, urinary bladder does not seem
to be a good material for a functional vagina.
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