In this study, we compared the diagnostic value of TROP-2 expression in distinguishing between benign and malignant thyroid lesions to those of HBME-1, CK19 and galectin-3. We selected 102 cases from our archive including 20 normal thyroid tissues, 23 follicular nodular diseases, 17 follicular adenomas, 20 follicular variant papillary carcinomas and 22 classical variant papillary carcinomas. Tissue microarrays constructed from these cases were immunohistochemically analyzed with HBME-1, CK19, galectin-3 and TROP-2. Respectively 73.8%, 83.3%, 69% and 50% of all papillary carcinomas were positive with HBME-1, CK19, galectin-3 and TROP-2. CK19 was positive respectively by 100%, 43.5% and 35.3% in cases of normal thyroid, follicular nodular diseases and follicular adenoma, while the other markers were negative. In distinguishing benign and malignant lesions, which constitutes this study, HBME-1, CK19, galectin-3 and TROP-2 were statistically significant (p < 0.001). In distinguishing cases of follicular variant papillary carcinoma from follicular nodular diseases and follicular adenoma, HBME-1 and galectin-3 were statistically significant (p < 0.001). Consequently, in this study, we found that all immunohistochemical markers were effective in distinguishing benign and malignant thyroid lesions. In determining malignancy, HBME-1 had the highest diagnostic accuracy, while CK19 was the most sensitive marker. The sensitivity increased when the markers were used together.

Anahtar KelimelerAlfa Bloker; BPH; Aşırı Aktif Mesane; Kombine Tedavi Abstract Aim: Effectiveness and reliability comparison of alpha-blocker monotherapy (doksazosin) and combined alpha-blocker+M3 selective antimuscarinic (doksazosin+darifenacin) treatments on male patients with Benign prostate hyperplasia and accompanying OAB (overactive bladder) symptoms. Material and Method: 101 patients with ages 50 and above who had LUTS (Lower urinary tract symptoms) complaints were included in the study. Patients were randomly organized into two groups. One group had treatment with 4mg doksazosin, the other group had 4mg doksazosin combined with 7.5mg darifenacin. Patients were evaluated in accordance with BPH manuals of EUA (European Urology Association) and AUA (American Urology Association). Patients were re-evaluated on 12th week after the treatment. International prostate symptom scores (IPSS), IPSS quality of life scores (IPSS-QoL), maximum urine flow rate (Qmax), average urine flow rates (AFR) and PVR (Post Voiding Residual Volume) data were obtained before and after the treatment from all patients. Results: Patients who received combined treatment had experienced considerable drop (p<0.01) in total IPSS and IPSS-QoL scores compared to monotherapy group. Qmax and and AFR data were found nearly equal (p=0.732). Considerable increase (p<0.01) in PVR (>43ml) in combined treatment group was observed. Discussion: Alpha-blocker+M3 selective antimuscarinic combined treatment is more effective than alpha-blocker monotherapy on male patients with LUTS secondary to BPH and OAB. However combined treatment causes considerable increase in PVR.

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Objective: The aim of this retrospective study was to investigate the lesions containing mature adipose tissues in surgical materials of the patients who underwent thyroidectomy operation owing to the diagnosis of nodular goiter.

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