In this work, the carbon paste electrode was modified with a composite of a metal‐organic framework, nitrogen‐doped graphite, and gold nanoparticles and used as an electrochemical sensor for dihydroxybenzene isomers. The morphology and characteristics of the modifiers were found by SEM and FT‐IR. Electrochemical techniques showed the specific surface of the electrode to be significantly enhanced. The outcome achieved shows that this novel sensor displays an excellent electro‐catalytic activity towards the oxidation of these isomers. The sensor was applied to the simultaneous determination of each three isomers using DPV with a linear response in the concentration range of 5–105 nM.
In this study a new electrochemical aptasensor has been represented for digoxin determination using signal-on strategy to improve limit of detection. To construct the sensor, gold screen printed electrode (GSPE) was modified with electrodeposited gold nanoparticles (GNPs) followed by self-assembling a layer of 3-mercaptopropionic acid (MPA) on the GNPs. Aminolabeled digoxin specific aptamer was covalently attached to the surface via carbodiimide bond formation. Graphene oxide (GO) was accumulated on the electrode surface through interaction with aromatic nucleobases in aptamer structure and the monitored reduction signal of potassium ferriciyanide as a redox probe was decreased. In the presence of digoxin, the immobilized GO left the surface and the current was increased and recorded as analytical signal. The proposed sensor was delivered a linear dynamic response over the range of 0.1 pM to 1.0 µM with a detection limit of 0.050 pM. The ability of the aptasensor in real sample analysis was successfully evaluated by determination of digoxin in human blood plasma samples with no serious matrix interferences.
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