A versatile and convenient method for synthesis of β-lactams using 3,6-dichlorotetrazine as an acid activator in the ketene-imine cycloaddition is reported. Monocyclic and spirocyclic β-lactams are obtained in good to excellent yields. Easy purification of the products can be performed by aqueous workup and then crystallisation from ethyl acetate.
A simple one‐pot protocol is presented for the synthesis of monocyclic and spirocyclic β‐lactams from carboxylic acids and aromatic imines with dichlorotetrazine as acid activator.
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