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Background: In developing countries like Nigeria, with poor socioeconomic , early marriage, poor acceptance of contraception, poor spacing of pregnancies, high fertility rate and poor maternal and child health indices, leading to poor maternal-child outcome. There is a need to investigate the pattern of serum lipid changes during pregnancy in Nigeria women as hyperlipidemia may lead to poor maternal outcome. Materials and methods: A total of one hundred and forty (140) subjects between the ages of 20 and 45 years with mean age 29.74 ± 6.5 years of the study population. Group 1: the control comprises of thirty-five (35) healthy non pregnant subjects with mean age of 26.84 ± 5.2 volunteers of Nigeria origin. Group 2: the test involved one hundred and five (105) apparently healthy pregnant Nigerian women subdivided into three groups; X, Y and Z each made of thirty-five (35) subjects distributed into 1 st , 2 nd and 3 rd trimester of pregnancy respectively. The TG assay was analyzed using enzymatic spectrophotometric method as described by Biosystems. Results: The result analysis showed a significant increase (p ≤ 0.05) in the TG level during the first trimester of pregnancy when compared with control as shown in Table 1. There was a significant increase (p ≤ 0.05) in the TG levels during the second trimester of pregnancy when compared with that of the control subjects. During the third trimester of pregnancy there was a significant increase in TG levels when compared with the control subjects. Conclusion: This work revealed that the most dramatic change in the lipid profile in normal pregnancy is serum hypertriglyceridemia, which may be as high as two-three folds in the third trimester over the levels in non pregnant subjects. The estimation of lipid profile is strongly recommended as part of the laboratory investigations during pregnancy.
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