Background and Objective: As the second cause of cancer-related death, gastric cancer (GC) is a major health challenge worldwide. Today, numerous efforts are underway to discover cancer biomarkers and drugs that affect these biomarkers. One of these biomarkers is the β-catenin protein, the expression of which has recently been shown to increase in GC. In addition, many ongoing efforts have focused on finding organic and natural medicines without the side effects of chemotherapy. One of these natural substances is honeybee propolis. In the present study, the effect of this extract was investigated on β-catenin gene expression in AGS cells.Materials and Methods: Propolis extract was applied to AGS cells at doses of 800, 1200, and 2000 μg/ml at intervals of 48 and 72 h. Next, the expression of this gene was evaluated by extracting RNA using the GAPDH as the reference gene. Finally, the difference in the β-catenin expression between the treatment and control groups was examined by data analysis.Results: A significant decrease was observed in the expression of the β-catenin gene in cells treated within 48 h, but no significant difference in the expression was found in the treatment at 72 h. However, the results are promising for the future use of honeybee propolis in cancer treatment in further studies.
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