A highly efficient multi-component one-pot synthesis of novel 1H-imidazo[1,2-a]imidazole-3-amine and imidazo[2,1-c][1,2,4]triazole-5-amine derivatives has been developed through the reaction of easily available aromatic aldehydes, benzoyl cyanide and either 2-aminoimidazole-4,5-dicarbonitrile or 3-amino-1,2,4-triazole in pyridine under controlled microwave heating. The process is environmentally friendly, is operationally simple, with short reaction time and with high yields.
A convenient one pot synthesis of pyrido[2,3-d]pyrimidines and pyrimido[2,3-c]pyrimidines via reaction of 6-amino-2-oxo-4-thioxotetrahydropyrimidine 1 with cinnamonitrile derivatives 2 has been reported.
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