Abnormal cord insertion, as well as intrauterine growth restriction, was determined to be correlated with the presence of CHD. On the basis of our results, we conclude that cord insertion should be evaluated at routine obstetric sonography, and further fetal heart evaluation is warranted if abnormal cord insertion is detected.
Background: Evidence is limited regarding the optimal therapeutic approach for neuropsychiatric symptoms associated with Parkinson’s disease dementia (PDD). Selective serotonin reuptake inhibitors (SSRIs) are widely used for mood disorders and behavioral symptoms in older adults with cognitive impairment, but they have limited efficacy in patients with PDD. The effect of SSRIs on hemostasis is also unclear. This report describes a patient with PDD who developed deep venous thrombosis (DVT) and hyponatremia after initiating citalopram (an SSRI) treatment. Case Presentation: An 86-year-old woman with PDD presented to our emergency department with altered mental status, generalized weakness, and left lower leg swelling. Citalopram was begun 4 weeks previously for behavioral changes and was discontinued 2 days before presentation because of excessive fatigue. At presentation, her plasma sodium level was 123 mg/dL. Brain computed tomography showed age-related changes. Doppler ultrasound revealed a DVT in the left lower leg. The patient was treated with hypertonic saline and intravenous heparin. After normalization of her sodium, she was discharged on donepezil and apixaban. At follow-up, her sodium remained normal, and her cognition and behavior were noticeably improved. Conclusion: Older adults with Parkinson’s disease are sensitive to adverse effects of psychotropic agents, especially SSRIs, which are not recommended first-line agents for behavioral symptoms in PDD. Upon initiating SSRIs in older patients with functional decline and multiple comorbidities, physicians should consider VTE prophylaxis, tailored to the patient’s needs and risk factors of bleeding or thrombosis. Physical activities should also be maintained as much as possible.
Background Evidence is limited regarding the optimal therapeutic approach for neuropsychiatric symptoms associated with Parkinson’s disease dementia (PDD). Selective serotonin reuptake inhibitors (SSRIs) are widely used for mood disorders and behavioral symptoms in older adults with cognitive impairment, but they have limited efficacy in patients with PDD. The effect of SSRIs on hemostasis is also unclear. This report describes a patient with PDD who developed deep venous thrombosis (DVT) and hyponatremia after initiating citalopram treatment. Case presentation An 86-year-old woman with PDD presented to our emergency department with altered mental status, generalized weakness, and left lower leg swelling. Citalopram was begun 4 weeks previously for behavioral changes and was discontinued 2 days before presentation because of excessive fatigue. At presentation, her plasma sodium level was 123 mg/dL. Brain computed tomography showed age-related changes. Doppler ultrasound revealed a DVT in the left lower leg. The patient was treated with hypertonic saline and intravenous heparin. After normalization of her sodium, she was discharged on donepezil and apixaban. At follow-up, her sodium remained normal, and her cognition and behavior were noticeably improved. Conclusion Older adults with Parkinson’s disease are sensitive to adverse effects of psychotropic agents, including SSRIs, which are not recommended first-line agents for behavioral symptoms in PDD. Upon initiating SSRIs in older patients with functional decline and multiple comorbidities, physicians need to evaluate the patient’s risk factors for bleeding or thrombosis. Physical activities should also be maintained as much as possible.
IntroductionDiabetes mellitus (DM) and dementia (DN) are common morbid disorders with high mortality, the two disorders shared the pathogenesis of proinflammation and insulin resistance. Polypharmacy is expected when DM and DN co-exist and medication adherence is essential to an effective self-care and management plan. This meta-analysis aimed to assess medication persistence among patients with diabetes and cognitive impairment (CogImp). MethodsWe systematically searched the literature through PubMed, Medline, Cochrane library, and the first 100 articles published in Google Scholar. We included articles publishes in English and conducted on humans, no limitation was set to the date of publication, all the articles were approached from the first published up to March 15, 2021. The keywords used were Dementia, cognitive impairment, cognitive decline, cognitive dysfunction, diabetes self-care, compliance to anti-diabetic drugs, and medication adherence. One hundredseventy-six were identified, the 12 full texts screened, only four fulfilled the inclusion and exclusion criteria. ResultsThe studies were published in Europe, the United States, and Asia (all were observational). The results showed no effects of dementia on medication adherence, P-value of 0.41, odd ratio: 1.09, 95% CI: 0.89-1.32, Chi-square for heterogeneity: 12.15, I 2 = 75%, and standard difference = 3. The P-value for heterogeneity was 0.007. The studies included 2,556 patients and 1,854 events. ConclusionNo association was found between dementia and compliance to anti-diabetic medications. Further prospective studies are needed to solve the issue.
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