In a restrospective study of 3,128 patients with primary melanoma, 90 were found to ha ve more than one primary lesion, an incidence of 2.9 %. Wfterever possible, comparisons were made between single and multiple primary lesion patients with reference to age. sex, racial bacfcground. skin, fiair, eye colouring, distribution and characteristics of tfte primary melanoma lesions. Patients with otie melanoma fiad a greater rl.sk of developing atiother atui their skin appeared to be more stisceptibie to sun damage. Patients with multiple abtiornial pigmented naevi also had an increased ri.sk of developitig a second pritnary melatioma. Having one primary lesion tended to alert both patient and doctor and resulted in earlier diagnosis of the second lesion. Althotigh tfiese patients developed multiple melanomas, their prognosis was more favourable tfmn in palients with a sltigle primary melanoma.
The Q-switched ruby laser was used to treat 101 amateur and 62 professional tattoos in 80 patients over a period of 22 months. Using a 5- to 8-mm spot size and energy fluences of 2-4 joules/cm2, an average of three retreatments resulted in complete pigment removal in four, nearly complete pigment removal in 84, significant pigment removal in 11, and minimal pigment removal in two amateur tattoos. Using identical parameters for professional tattoos, there was complete pigment removal in two, nearly complete pigment removal in five, significant pigment removal in 18, minimal pigment removal in 25, and very little pigment removal in 12. Professional tattoos with red, yellow, and green pigments faded, but required multiple retreatments. While transient hypopigmentation occurred in many patients, skin texture and hair growth returned to normal in all cases and no hypertrophic scarring was seen.
A low power, argon-pumped tunable dye laser was used to deliver yellow light of 577 nm. Individual blood vessels within port-wine stain hemangiomas were treated with a 0.1-mm beam of light using 8 X magnification. This technique permits excellent resolution of facial and nuchal port-wine stain hemangiomas in adults without the adverse complications of textural change, permanent pigmentation abnormality, or hypertrophic scarring.
Langerhans cells and melanocyte distribution was determined in 18 different body sites in 76 cadavers, 44 men and 32 wotnen, within 24 hours of death. The Langerhans cell and melanocyte counts were inversely related so that in sun-exposed (tanned) epidermis Langerhans cell number.^ were lower and melanocyte numbers were higher than in nott-exposed (non-tanned) epidertnis. Langerhatis cell atid tnelatwcyte densities were sitnilar in tnen and wottien on non-exposed (non-tanned) epidertnis when matched by age. In atiy one subject Langerhans cell detisities were even throughout the body except on sun-exposed (tanned) areas, where Langerhans cell counts were not only significantly tower but the cells were also unevenly distributed. Langerhatis cell counts for all body areas decreased with age in both tnen and wotnen.
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