Researches on DH have shown that it is not just a bullous skin disease, but a
cutaneous-intestinal disorder caused by hypersensitivity to gluten. Exposure to
gluten is the starting point of an inflammatory cascade capable of forming
autoantibodies that are brought to the skin, where they are deposited, culminating in
the formation of skin lesions. These lesions are vesico-bullous, pruritic, and
localized especially on elbows, knees and buttocks, although atypical presentations
can occur. Immunofluorescence of perilesional area is considered the gold standard
for diagnosis, but serological tests help in cases where it is negative. Patients who
follow glutenfree diets have better control of symptoms on the skin and intestine, as
well as lower risks of progression to lymphoma. Dapsone remains the main drug for
treatment, but it requires monitoring of possible side effects, some potentially
lethal.
RESUMOO piloleiomioma é uma neoplasia benigna de musculatura lisa originada no músculo eretor do pelo. As lesões podem ser solitárias ou em grande número, acometendo frequentemente as extremidades. Costuma apresentar dor espontânea ou após estímulos físicos como frio e pressão. Relata-se um caso de piloleiomiomas múltiplos dolorosos em paciente masculino, que foi bem controlado com o uso de nifedipina..
PALAVRAS-CHAVE: leiomioma, pelo, músculo liso, neoplasias cutâneas.
ABSTRACTPiloleiomyoma is a benign smooth muscle neoplasm which arises from the erector pilorum muscles. Lesions can be single or multiple and more frequently involve extremities. Pain may occur spontaneously or after physical stimulation (cold and pressure). The authors report the case of multiple painful piloleiomyomas in a man, that was well controlled with nifedipine.
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