This study informs medical professionals about the importance of tailoring information to the needs of the individual patient, and we feel it provides insights into the successes and failures of our communication with cancer patients. It is important that difficult discussions are personalized to the individual patients' wishes. These can vary dramatically both in the area of disclosure of bad news in prognosis and in end-of-life decision making. This study provides compelling evidence for good advanced care planning at an early stage in the management of patients with terminal cancers.
Highlights► The absence of TLR4 is associated with reduced endothelial cell function in mesenteric arteries. ► TLR4−/− mouse arteries have reduced acetylcholine responses. ► TLR4−/− have increased superoxide levels when stimulated with acetylcholine. ► An increase in superoxide generation reduces the activity of endothelial derived nitric oxide.
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