A new series of 1,3-substituted pyrrolidine-2,5-dione derivatives as potential anticonvulsant agents are described. Initial pharmacological screening of these compounds was performed by using acute models of seizures (MES and scPTZ tests) in mice after intraperitoneal administration. Quantitative pharmacological research revealed that the most promising compounds were N-[{4-(3-trifluoromethylphenyl)piperazin-1-yl}propyl]-3-benzhydrylpyrrolidine-2,5-dione monohydrochloride (11) with a ED value of 75.9 mg kg (MES test) and N-[{4-(3,4-dichlorophenyl)piperazin-1-yl}ethyl]-3-methylpyrrolidine-2,5-dione monohydrochloride (18) with ED =88.2 mg kg (MES test) and ED =65.7 kg mg (scPTZ test). These compounds displayed a more beneficial protective index than well-known antiepileptic drugs. A plausible mechanism of action of compounds 11 and 18 [molecule 11 blocked the sodium channel (site 2) and 18 blocked both the sodium (site 2) and L-type calcium channels] and their preliminary safety in vitro were evaluated. Besides, the lipophilicity of all synthesized compounds was determined by using UPLC-MS.
Job satisfaction survey among pharmacist employed in community pharmacies in Poland • Many years of pharmaceutical education, providing graduates of the pharmaceutical faculty with obtaining the right to practice, numerous courses, trainings, conferences, activities aimed at steadily increasing their professional skills seems to be taking very important actions by pharmacists, towards introducing changes in the perception of the contemporary image of the profession of pharmacist among patients Meanwhile, the stereotype of the approach of pharmacypatient clients to the role of an apothecary as a salesperson (rather than as a consultant in matters of patient's health and illness) seems to be one of the key factors affecting the level of job satisfaction by pharmacists.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.