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486BLOOD COPPER AND IRON I N ADDISON'S DISEASE ence of action than any of the 3 other substances examined. This property of the propionate was still more striking in the small number of short interval (36 hours) experiments. The unit dose was considerably higher under these conditions but the action persisted more than 20 days.The absolute values obtained in this study may require revision. Various circumstances indicate that they will be found somewhat lower in a larger series of experiments, when the experimental conditions are better established as, for instance, the volume of the hormone solution injected and the time interval between tests on the same animal. However, if the general results of these experiments are confirmed in a larger series of tests, a new bio-assay method becomes available which offers several advantages, Viz., animals need not be sacrificed, autopsy and histological examinations or measurements of organs are not required, and the persistence of action can be registered on the individual animal continually.

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