ObjectiveIn an admixed population of older Cubans, the incidence and association of APOE and sociodemographic risk factors with dementia incidence was estimated.MethodsA single-phase survey (baseline) of all over 65-year-olds residing in seven catchment areas in Cuba (n=2944) was conducted between 2003 and 2007. Dementia diagnosis was established according to DSM-IV and 10/66 criteria. APOE genotype was determined in 2520 participants. An incidence wave was conducted 4.5 years after cohort inception in order to estimate incidence and associations with sociodemographic risk factors of the APOE ε4 genotype.ResultsThe incidence rate of DSM IV dementia was 9.0 per 1000 person-years (95% CI 7.2-11.3) and of 10/66 dementia was 20.5 per 1000 person-years (95% CI, 17.6-23.5). Older age, a family history of dementia and APOE ε4 genotype were independent risk factors for incident 10/66 dementia. APOE genotype was associated cross-sectionally with dementia prevalence, but the effect on the incidence of dementia was attenuated, and only apparent among those in the youngest age group.ConclusionThe incidence of dementia in the older Cuban population is relatively high and similar to levels reported in Europe and North-America. The study showed that the relationship between APOE ε4 and incident dementia is stronger in the younger-old than the older-old and that this change must be taken into account in models of dementia.

Stroke incidence was similar to rates reported in developed countries and lower than that in low- to middle-income countries. Given that diabetes mellitus, heart disease, arterial hypertension, smoking, APOE4, etc. are associated with higher mortality rates, they will require separate analysis in a study of stroke risk factors.

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Background:An association between APOE e4 carriage and dementia and Alzheimer's disease (AD) is consistently observed in European ancestry populations, with an attenuated effect in those with African or mixed ancestry. In an admixed population of older Cubans we explored the effects of ethnic identity and genetic admixture on APOE genotype, its association with dementia prevalence and incidence. Methods: We conducted population-based prevalence (n¼ 2 944) and incidence (n¼ 2 812 surveys in catchment area survey of Havana and Matanzas,Cuba, residents aged 65 and over. Dementia diagnosis was established using 10/66 Dementia and DSM-IV criteria. APOE genotype was determined in 2520 participants, and genetic admixture in 235 dementia cases and 349 controls. Results: The APOE association with dementia prevalence was 3.38 (CI 95% 2.48-4.60) and lower with Incidence dementia, SHR 1.56 (1.19-2.04). African admixture was associated with APOE e4 carriage but seemed to attenuate the association with prevalent dementia. There was no main effect of African admixture on dementia prevalence. Conclusions: APOE e4 allele carriage is associated with an increased prevalence and incidence of dementia in populations characterized by African/ European admixture. Population stratification did not affect risk associations. The possibility that African ancestry may attenuate the risk in APOE e4 carriers requires confirmation with larger samples. Associations with prevalence were stronger than those with incidence, probably explained by earlier age at onset for APOE e4 carriers, rather than prevalence bias.Background: P-values for selection of single nucleotide polymorphisms (SNPs) have suffered from high false positive and false negative results. This study was aimed to compare the application of clinical-based index and p-value for marker selection. Methods:

AD studies to AD-relevant sequence features and genome-wide annotations. Results: As of January 2016, NIAGADS houses 34 datasets with almost 50k subjects and over 30 billion genotypes. With the completion of the ADSP Discovery Phase, qualified investigators can retrieve sequencing data with ease and flexibility using the ADSP website and data portal (collaboration with dbGaP/SRA). The ADSP generated sequencing data of >11,000 subjects; raw data as well as quality controlled VCF files are available through the ADSP portal and dbGaP (phs000572). Conclusions: With a streamlined application and submission process, NIAGADS is a rich resource for AD researchers to utilize. Datasets, guidelines, and new features are available on our website at https://www. niagads.org and https://www.niagads.org/adsp/.