Purpose: To evaluate the hyperlipidemic potential of the methanolic-aqueous extract of Typha domingensis Pers.Method: Hyperlipidemia was induced in Wistar rats with high fat diet (HFD). The animals were divided into five groups; normal control group was administered normal diet and water ad libitum; whereas, all other groups were given HFD along with respective treatment; i.e., positive control group (normal saline, 1 ml/kg; p.o.), standard control group (atrovastatin 5 mg/kg; p.o.) and treatment groups received 70 % methanolic-aqueous extract of Typha domingensis (TD.Cr) at the 100 and 300 mg/kg p.o. After 28 days, the animals were weighed, blood was collected and sera separated. Aortas were dissected out for histological studies. Sera were analyzed for total cholesterol, triglycerides, HDL and LDL. Hypotensive effects were evaluated through invasive technique followed by diuretic activity.Results: Typha domingensis extract significantly lowered the levels of total cholesterol, triglycerides, and LDL to 132.30 ± 1.145, 161.50 ± 1.33 and 41.67 ± 1.28 mg/dL, respectively, at 100 mg/kg (p < 0.001) and 111.50 ± 1.05, 157.70 ± 1.74 and 29.17 ± 0.98 mg/dL, at 300 mg/kg, respectively (p < 0.001). It produced anti-obesity effects represented as reduction in body weight by 17.00 ± 1.29 to 1.5 ± 7.63 g (p < 0.001) from 100 to 300 mg/kg, respectively, compared to control. Histological studies revealed the anti-atherosclerotic effect of the plant extract. A decreasing mean arterial blood pressure revealed hypotensive effects.Conclusion: Typha domingensis has a potential for the treatment of diet-induced hyperlipidemia and associated complications. However, clinical investigations are required to buttress these assertions.
Obesity, a chronic metabolic condition, is an increase in fat mass and blood lipid levels mainly causing atherosclerosis and hypertension, which further lead to cardiovascular complications. The objective of the study was to investigate the crude extract of Caralluma edulis (CE.Cr) for its potential against high-fat diet (HFD)-induced obesity and its related complications. Hyperlipidemia was induced in Wistar albino rats with HFD (1% cholesterol + 0.5% cholic acid) for 28 days. Treatment groups were administered with different doses of CE.Cr (100, 300 and 500 mg/Kg, p.o.) and the standard group received atorvastatin. At the end of study, sera were analyzed for biochemical markers and the aorta was dissected for microscopic examination. Antioxidant potential was evaluated and high-performance liquid chromatography (HPLC) analysis was performed. The hypotensive potential of CE.Cr was evaluated through an invasive technique. HPLC analysis of CE.Cr showed the presence of chlorogenic acid, caffeic acid, apigenin and naringenin. Histological examination of the aorta section showed anti-atherosclerotic effects which were also evident from decrease in serum total cholesterol, triglycerides and low-density lipoproteins levels. CE.Cr decreased mean arterial blood pressure and evoked significant hypotensive effects. The crude extract of C. edulis showed anti-obesity, antihypertensive, anti-atherosclerotic and antioxidant potential.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.