Objective: The potential eects of ethnicity, gender, and adiposity on the serum lipid pro®le in persons with spinal cord injury (SCI) were determined. Subjects: Subjects with SCI were recruited during their annual physical examination from Rancho Los Amigos Medical Center, Downey, California. Sedentary able-bodied controls were Bridge and Tunnel Ocers of the Triboro Bridge and Tunnel Authority of the New York City metropolitan area. Methods: Serum lipid pro®les were investigated in 320 subjects with SCI and compared to those obtained from 303 relatively sedentary able-bodied controls. Serum lipid studies were obtained in the fasting state. Data were collected between 1993 and 1996. All lipid determinations were performed by the same commercial laboratory. Main outcome measures: The dependent variables were the values from the lipid pro®le analysis. The independent variables consisted of study group, gender, ethnic group, age, duration of injury, and anthropometric measurements. Results: The serum high-density lipoprotein cholesterol (HDL-c) level was reduced in the SCI compared with the control group (mean+SEM) (42+0.79 vs 47+0.67 mg/dl, P50.0005). The serum HDL-c level was signi®cantly lower in males with SCI than males in the control group (39+0.83 vs 45+0.70 mg/dl, P50.0001), but not for females (51+1.54 vs 54+1.52 mg/ dl, n.s.). Within the subgroups for whites and Latinos, HDL-c values were also lower in subjects with SCI than in controls (whites: 41+1.02 vs 46+0.86 mg/dl, P50.0001; Latinos: 37+1.53 vs 42+1.59 mg/dl, P50.05), but not for African Americans (49+1.56 vs 51+1.27 mg/dl, n.s.). African Americans had higher HDL-c values than whites or Latinos (SCI: 49+1.56 vs 41+1.02 or 37+1.53 mg/dl, P50.0001; controls: 51+1.27 vs 46+0.86 mg/ dl, P50.01 or 42+1.59 mg/dl, P50.0005). In persons with SCI, the serum HDL-c values were inversely related to body mass index and estimated per cent body fat (r=0.27, P50.0001). Conclusion: In white and Latino males, but not in females or African Americans, immobilization from SCI appears to be associated with lower HDL-c values than in controls.
Objective: To determine the expected vital capacity in persons with chronic spinal cord injury (SCI) in relation to injury level, completeness of injury, smoking and duration of injury, as an aid to diagnosis and management of respiratory complications. Setting: A New York City veterans' hospital and a Los Angeles public rehabilitation hospital. Methods: Case series from the two hospitals were pooled. Participants (adult outpatients with SCI of duration 41 year, not ventilator-dependent) were evaluated by conventional forced expiratory spirometry. Cross-sectional analysis was performed, using multiple regression, on the entire population and de®ned subgroups. The principal outcome measure was forced vital capacity (FVC). Results: In the subjects with complete-motor lesions, FVC ranged from near 100% of normal predicted values in the group with low paraplegia, to less than 50% in those with high tetraplegia. Incomplete lesions mitigated FVC loss in tetraplegia. In subjects with paraplegia, longer duration of injury was associated with greater loss, and smoking-related loss was evident at older but not at younger ages, presumably due to greater pack years in older subjects. Conclusions: Vital capacity/SCI level relationships determined here may have diagnostic and prognostic value. Smoking-related FVC loss is important in persons with SCI as in others, although at higher levels it may be obscured by SCI-related loss.
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