Paraquat is an environmental pollutant that is associated with some disorders including alteration of some harmatological indices and is a concern to public health. Vitamin E has antioxidant property and other characteristic roles that ameliorate toxic effect. 200 male albino rats weighing 0.2±0.02kg on the average were divided into four main groups (A, B, C, and D) with 50 rats in one group. The “A” group was not served paraquat solution and was used as the control group. Group “B”, “C”, “D” being the treatment group were given dose rates of paraquat of 0.02g, 0.04g, and 0.06g, of paraquat per kg rat respectively every two weeks for three months. The main groups further had subgroups. “A”, “A0” and “AVE”; “B”, “B0” and “BVE”; “C” had “C0” and “CVE”; and “D”, “D0” and “DVE” subgroups. Vitamin E was not given to subgroups “A0”, “B0”, “C0” and “D0” subgroups while “AVE”, “BVE”, “CVE” and “DVE” were fed orally with 500mg of vitamin E therapy every week. Treatment with vitamin E began three months after paraquat treatment. At the end of the weekly treatment with vitamin E for a month, the rats were sacrificed and their blood samples were obtained and analyzed for PCV, Hb, WBC, neutrophil and lymphocyte. A0, B0, C0 and D0 intergroup comparison was statistically significant, p-value<0.05 in PCV and Hb levels while their WBC, neutrophil and lymphocyte had no statistical significance. Ave, Be, Cve and Dve intergroup comparison was statistically significant, p-value<0.05 in PCV and Hb levels while WBC, lymphocyte and neutrophils had no statistical significance among the groups. Intra group comparison showed that only PCV and Hb were significant between groups, p-value<0.05. This study confirms that vitamin E is potent in treating paraquat toxicity in male albino rats on one month of weekly treatment.
Background/Objectives: Plasmodium falciparum malaria is the commonest cause of childhood mortality in Africa with varied hematology consequences hence, this study aims to evaluate erythrocyte indices of children with P. falciparum infection in other to elucidate infant's erythrocyte condition during falciparum infection.Materials and Methods: 243 subjects participated in this study comprising 124 (71females and 53males) experimental group with mean age of 24±3.8months and 119 (68females and 51males) controls group with mean age of 27±6.1months. 2ml of venous blood were collected from participants into K3-EDTA vacutainer. Erythrocyte indices and leucocyte counts were determined within 4hours of blood collection using Sysmex XN550 hematological analyzer.Results: Erythrocyte count of subject with P. falciparum infection was 2.63±0.9x10 12 /l while Erythrocyte level of control group was 4.31±0.8x10 12 /l at P<0.05. RDW-CV of subjects was 16.5±0.1% while RDW-CV of control was 13.2±0.9%. Hemoglobin level of subject and control was 6.9±1.1g/dl and 12.3±1.2g/dl respectively and MCV of subject was 86.7±1.3fl while that of the control group was 75.3±1.0fl. MCH of control and subject groups were 25.8±0.5pg and 26.2±0.2pg respectively and the value of MCHC of subjects was 30.3±0.6g/dl while MCHC of control group was 33.9±0.4g/ dl at P<0.05. Total leucocyte count of subjects and control group were 7.13±0.4x10 9 /l and 8.9±1.6x10 9 /l respectively and neutrophil counts of children with P. falciparum infection was 3.94±0.2x10 9 /l while neutrophil count of control was 3.5±2.9x10 9 /l. Conclusion:Children with Plasmodium falciparum infection in Yola had higher MCV and RDW-CV values with lower erythrocyte count, hemoglobin and MCHC value and no significant difference in leucocyte counts when compare with control group.surgery it is frequently of interest to measure different parameters simultaneously. The goal of this work was to find an optimal system for this purpose and to build up a multichannel temperature measuring system. We selected a highly flexible system, which also provides Ethernet compatibility in conjunction with relatively easy development of specific software. Specifically, the temperature measurement component was realized with Pt-1000 sensors, which were connected to the base in four-wire link. First tests after calibration showed stable and reproducible values over a long time period. The system works well, and it can be adapted in a way to allow measurements of further physical parameters in the near future.
Bee sting envenomation results in alteration of hematological parameters but in Yola, information regarding effect of bee sting envenomation on hematological parameters of children is not well documented. This study therefore aims to examine the effect of bee sting envenomation on children in Yola. 133 subjects participated in this study, comprising of 64(female = 21, male = 43) children with mean age of 48±3.8months having bee sting envenomation and 69(female = 31, male 38) apparently healthy children without bee stings with mean age of 47±6.1months. Hematological parameters of all subjects were determined using Sysmex XN550 hematology analyzer. Mean red cell count of subject was 4.39±0.3 X10 6 /µl while red cell count of control group was 4.31±0.3 X10 6 /µl at P<0.05. Platelet Distribution Width (PDW) of subject group was 8.5±0.4fl while PDW of control group was 11.5 ± 1.2fl. Moreover, Mean Platelet Volume (MPV) of subject and control group was 9.2±0.6fl and 9.4 ± 1.4fl respectively while subjects had Platelet Large Cell Ratio (P-LCR) of 17.9±1.0% while the control group had P-LCR of 23.4 ± 2.1%. Furthermore, mean total white cell count of subjects and control group were 28.9±1.4 X10 3 /µl and 8.9±1.6 X10 3 /µl respectively and neutrophil counts of children with bee sting envenomation was 23.9±2.7 X10 3 /µl while neutrophil count of control group was 3.5±2.9 X10 3 /µl. Neutrophil count and total white cell count showed a significant value increase while P-LCR and MPV had a lower value in subject when compare to the control group in this locality.
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