Takayasu arteritis (TAK) is an autoimmune disease majorly affecting young females. It alters the vascular wall, resulting in stenosis, occlusion, or dilatation. It has no distinct clinical manifestation. Here, we present the case of an 18-year-old girl who presented with generalized tonic-clonic seizure and hypoxia. Blood investigations showed deranged urea and creatinine values. Computed tomography angiography revealed bilateral artery occlusion, decreased kidney size, and pulmonary artery dilatation, confirming generalized vascular disease that caused hypertension and ischemic nephropathy in the patient. Our case represents a rare autoimmune disease, leading to pulmonary hypertension and renal artery stenosis. TAK should be considered as a differential diagnosis in young female patients presenting with pulmonary as well as renal signs and symptoms, especially if there is discrepancy in blood pressure levels in all limbs. Case summary- An 18yr old girl presented with generalized tonic-clonic seizure and hypoxia. Blood investigations showed deranged urea and creatinine values. CT angiography revealed occlusion of bilateral arteries along with decreased size of both the kidneys. It also revealed pulmonary artery dilatation and hence generalized vascular disease was confirmed which caused hypertension along with ischaemic nephropathy in the patient. Discussion- Our case represents a rare autoimmune disease leading to pulmonary hypertension and renal artery stenosis. Whenever young female patients present with associated pulmonary as well as renal signs and symptoms, Takayasu arteritis should be considered as a differential diagnosis,especially if there is discrepency in blood pressure levels in all four limbs.
Complications of chronic kidney disease (CKD) impair cardiovascular health and quality of life. Health-related QoL (HRQoL) is influenced by cultural perspectives, social environment and health behaviors that vary across countries with varying income. Therefore, present review aims to report HRQoL in people with CKD and factors influencing HRQoL in low- and middle-income countries (LMICs). Fifty relevant studies were reviewed following literature search in Cochrane Library, PubMed, Google Scholar and CINAHL databases using key words: quality of life, CKD, and LMICs. HRQoL was poor in people with CKD compared with healthy individuals. QoL was positively influenced by younger age, male gender, employment and higher socioeconomic status. Presence of comorbidities, anemia and low hemoglobin levels were associated with poor QoL. Intrinsic and extrinsic factors influencing HRQoL were similar in people with CKD in LMICs and high-income countries (HICs). However, overall HRQoL and mental-health scores were lower with reference to HICs. Therefore, a multipronged approach designed towards prevention of kidney disease, early detection and management to delay end-stage kidney disease through health education, modification of risk factors, accessible and affordable comprehensive management of kidney disease is necessary. In resource constrained settings of LMIC, strategic investment in planning and implementation of prophylactic and monitoring measures will help to reduce huge financial costs necessary for management and improvement of HRQoL of people with CKD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.