: Calcium hydroxide (Ca(OH)2) has been used as a root canal medicament due to its antimicrobial activity and organic tissue dissolution capacity. To, increase the efficiency and success of root canal/endodontics treatment calcium hydroxide has to be removed from the canals walls. This study evaluate and compare four different irrigation system i.e. Conventional Irrigation (plastic 30 gauge needle), Sonic Irrigation ( Endoactivator), Ultrasonic Continuous Irrigation and Negative pressure with Endo Irrigation plus.For carrying out this study we have used 50 extracted premolar roots, preserved in sodium hypochlorite. Then they were randomly allocated five in four groups (n=10) and a control group. Specimen were statistically analysed by Kruskal Wallis test. All Testing was performed at significance level P-values 0.05. The analysis was carried out with social sciences version (SPSS)17.0 for Windows(SPSSInc.,Chicago, IL,USA). : In our present study we have found that None of the techniques used was completely able to remove Ca(OH)2 from the root canals. But the Sonic irrigation system (Endoactivator) has some potential benefit in removal of calcium hydroxide.
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