The most common organism of acute viral gastroenteritis is norovirus, which accounts for roughly 20% of all occurrences of acute gastroenteritis globally. The virus kills over 200,000 children each year and is the leading cause of childhood diarrhea in the rotavirus-vaccinated population. This study aims to review available studies regarding the information on the genogroup norovirus in humans, development of norovirus vaccines, and effectiveness of norovirus vaccines. A systematic review using Science Direct, PubMed, and Scopus databases to identify eligible case studies. The search was conducted in September-October 2021. The quality of the included literature used checklists from the Critical Appraisal Skills Program (CASP). All of the six selected studies with populations given RT-PCR intervention showed positive for norovirus infection. The most predominant genogroups in humans are GI and GII. As for the research results of the two selected studies on norovirus vaccine, namely the human phase 2 trial containing two Virus-Like Particles (VLP) genotypes, one study showed efficacy at 18-49 one study at ≥ 60 years of age. This study analysis uses Takeda bivalent vaccine. The vaccine includes norovirus antigens of the GI and GII genogroups, intending to expand its protective immune potential. GI, GII, and GIV genogroups are prevalent in humans. VLP that contains GI.I and consensus GII.4c have been created as the NoV vaccine, providing signifi cant efficacy. Very likely because they contain GI dan GII antigens, which are the genogroups that infect humans the most. Patients given a placebo developed acute gastroenteritis due to norovirus GII.2, indicating a genotype cross-reactivity.
Infeksi Covid-19 dapat menyebabkan gejala akut pada penderitanya. Pasien dapat mengalami mialgia, anosmia, hidung tersumbat, sakit tenggorokan, dan/atau diare. Penyebaran Covid-19 tergolong sangat cepat dan mudah serta dapat menginfeksi semua golongan umur. Hingga saat ini, belum ditemukan terapi yang dapat menyembuhkan penyakit ini. Oleh karena itu, vaksin menjadi salah satu alternatif yang paling banyak digunakan untuk mencegah penularan Covid-19. Penelitian ini disusun berdasarkan kajian systematic review dengan menggunakan PRISMA flowchart. Artikel diperoleh dari basis data Science Direct, PubMed, dan Google Scholar yang diterbitkan pada tahun 2020-2021. Anak-anak lebih rendah kemungkinan terinfeksi Covid-19 dengan gejala yang lebih ringan dibandingkan dengan orang yang lebih tua. Vaksinasi pada anak-anak dapat meningkatkan daya tahan tubuh untuk mencegah infeksi Covid-19. Vaksin BCG dan BNT162b2 efektif dan aman digunakan pada anak-anak. Vaksinasi pada anak-anak efektif mencegah infeksi Covid-19.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.