BACKGROUND OF THE STUDY: Prabotulinumtoxin A (PRA) is the newest type A botulinum toxin produced by wild-type Clostridium botulinum. Prabotulinumtoxin A has a higher purity level than onabotulinum toxin A, but the literature discussing it is still limited and requires more research on its effectiveness. AIM OF THE STUDY: This research aimed to examine the efficacy of Prabotulinumtoxin A on wrinkles in forehead, crow’s feet and glabellar. METHODOLOGY: This research was a pre- and post-test, multicenter study from 3 center in Indonesia. Subjects will be observed at week 0, week 2, week 4, week 8 and week 12. Injection of prabotulinumtoxin A (INIBOÒ, Covaltt, South Korea) was performed intramuscularly on forehead, crow's feet, and glabellar with a dose of 4 IU / 0.1 ml. The measurement uses a scoring from the Upper Face Rating Scale. Different statistical test with repeated measurement test was conducted to compare the results between observations. The statistical test uses a confidence level of 0.95 with an error rate (α) = 0.05. RESULTS: The results of this study showed that Prabotulinumtoxin A injection was effective in reducing wrinkles in the frontal, glabellar and crow's feet area, with a statistically significant difference between week 0 and week 12. CONCLUSION: Prabotulinumtoxin A products improve the condition of wrinkles with a fairly good level of satisfaction and efficacy. Observations of more than 12 weeks are needed to determine the duration of Prabotulinumtoxin A products.
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