Systemic lupus erythematosus (SLE), an autoimmune inflammatory disease, is associated with an increased prevalence of accelerated atherosclerosis and cardiovascular events. Metabolic syndrome (MetS) is a set of cardiovascular risk factors in SLE patients, which may lead to a proinflammatory condition and increased morbidity and mortality. The objective of this study was to evaluate the prevalence of MetS in a cohort of SLE patients versus healthy controls, and to analyze the association of clinical and demographic factors. SLE patients (n = 146) treated at a Northeast Brazilian university hospital were evaluated with regard to demographic, clinical, laboratory, and anthropometric parameters and compared to controls (n = 101). MetS was diagnosed according to the definition of 2005 NCEP/ATP III. The average age of SLE patients was 41.7 ± 12.5 years, and 91.8 % were female. MetS was significantly more prevalent in SLE patients (45.2 %) than in controls (32.7 %; p = 0.04). The MetS components such as hypertension, diabetes, and hypertriglyceridemia were significantly more prevalent in SLE. In the univariate analysis, MetS in SLE patients was associated with age, disease duration, Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index, smoking, menopause, nephritis, cyclophosphamide use, prednisone dose, and chloroquine use, which appeared to have a protective effect. In the logistic regression analysis, age, disease activity, nephritis, and smoking were statistically significant. The prevalence of MetS observed in our cohort of SLE patients from Northeastern Brazil is higher than controls. MetS components should be routinely investigated to minimize the occurrence of MetS and associated cardiovascular morbidity and mortality.
Z^hDKO tratamento da artrite reumatoide (AR) visa prevenir dano articular irreversível e inclui o uso de drogas sintéticas e biológicas. O REMHWLYR GHVWH HVWXGR IRL DYDOLDU R SHU¿O GR XVR GH LPXQRELROyJLFRV QD DUWULWH UHXPDWRLGH QR VHUYLoR GH UHXPDWRORJLD GR +8:& (VWH HVWXGR REVHUYDFLRQDO UHWURVSHFWLYR H WUDQVYHUVDO LGHQWL¿FRX SDFLHQWHV FRP $5 HP XVR DWXDO RX QRV ~OWLPRV DQRV GH DJHQWHV ELROyJLFRV )RUDP FROHWDGRV HP HQWUHYLVWD H UHYLVmR GH SURQWXiULR GDGRV GHPRJUi¿FRV FOtQLFRV H WHUDSrXWLFRV LQFOXLQGR a presença de eventos adversos e infecções relacionadas às drogas prescritas. Nossa amostra se constituiu de subgrupo de pacientes com doença grave e baixo nível socioeconômico. Os imunobiológicos mais utilizados foram os anti-TNF. Cerca de metade dos SDFLHQWHV DSUHVHQWRX VFUHHQLQJ SRVLWLYR SDUD 7% ODWHQWH 2 SHU¿O GH XVR GRV DJHQWHV ELROyJLFRV QR WUDWDPHQWR GRV SDFLHQWHV FRP diagnóstico de AR encontra-se em concordância com as recomendações clínicas vigentes.
Palavras-chave: $UWULWH UHXPDWRLGH 7HUDSrXWLFD $JHQWHV DQWLUUHXPiWLFRV 7HUDSLD ELROyJLFD 7XEHUFXORVH ODWHQWH
ABSTRACT
Rheumatoid arthritis (RA) treatment is intended to prevent irreversible joint damage and includes the use of synthetic and biologic GUXJV 7KH DLP RI WKLV VWXG\ ZDV WR HYDOXDWH WKH SUR¿OH RI ELRORJLF DJHQWV XVH LQ UKHXPDWRLG DUWKULWLV LQ D VLQJOH EUDVLOLDQ FHQWHU RI UKHXPDWRORJ\ 7KLV REVHUYDWLRQDO UHWURVSHFWLYH DQG FURVVVHFWLRQDO VWXG\ LGHQWL¿HG SDWLHQWV ZLWK 5$ LQ DFWXDO RU SUHYLRXV XVH LQ WKH ODVW ¿YH \HDUV RI ELRORJLF DJHQWV 7KHUH ZHUH FROOHFWHG LQ DQ LQWHUYLHZ DQG FKDUW UHYLHZ GHPRJUDSKLF FOLQLFDO DQGtherapeutic data, including the presence of adverse events and infections related to prescription drugs. Our sample consisted of subgroup of patients with severe disease and low socioeconomic status. The biologic drugs most used were the anti-TNF. About KDOI RI WKH SDWLHQWV KDG SRVLWLYH VFUHHQLQJ IRU ODWHQW 7% 7KH XVDJH SUR¿OH RI ELRORJLFDO DJHQWV LQ WKH WUHDWPHQW RI 5$ GLDJQRVHG patients is in line with current clinical recommendations.
Introdução: a importância da face para o convívio social faz com que defeitos cirúrgicos na região representem desafios reconstrutivos. Particularmente as regiões do nariz e canto de olho apresentam dificuldades reconstrutivas inerentes ao tipo de pele e funções. Bastante utilizado, o retalho médio-frontal tem a desvantagem de necessitar de dois tempos operatórios, elevando gastos e expondo o paciente a semanas de condição estética bastante desagradável. Proposta por Kersidag, a modificação da técnica com a ressecção da pele do pedículo e tunelização subcutânea para região distante como a ponta de nariz permite a cirurgia em tempo único. Objetivo: o presente trabalho objetiva demonstrar que a técnica de Kersidag é segura e adequada. Metodologia: como procedimento metodológico, recorremos a referências bibliográficas sobre a temática e realizamos procedimento com base nas modificações descritas. Resultados: três pacientes do sexo feminino, de 64 a 81 anos foram submetidos à técnica, com reconstrução com excelente resultado estético e sem nenhuma perda de retalho em todos os casos. Conclusão: concluímos que a técnica de Kersidag é uma opção viável e segura para reconstrução de defeitos em ponta nasal e em canto de olho em único tempo sem prejuízos estéticos ou funcionais.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.