Congenital malformations are one of the leading causes of neonates and infants’ mortality and morbidity. The frequency of these congenital malformations varies in different populations. The objective of this study was to find out the prevalence and pattern of congenital malformations in a tertiary teaching hospital in Rabat, Morocco. This four-year retrospective descriptive study was conducted from January 2011 to December 2014. All newborns with congenital malformations diagnosed at birth were included. Mothers and newborn characteristics were analyzed using SPSS 13.0. A total of 706 newborns were noted to have congenital malformation. The prevalence rate was 1.02%. The mean maternal age was 28.8±7.2 years. The mean maternal body mass index was 28.1±6.9 kg/m2. 13.3% of the mothers had a history of abortion. The nervous system was the most affected system (19.4%) followed by the musculoskeletal system (14.2%), the chromosomal abnormalities (12.3%) and the genito-urinary system (10.8%). Males newborns (57.9%) had more congenital malformations than females (40.5%). The rates for live-births, fetal asphyxia and stillbirths were 75.2%, 7.2% and 17.3%, respectively. This retrospective study provides recent and detailed data about congenital malformations in a Moroccan region. The result from this study will contribute to the knowledge of congenital malformations in this particular area and hence the supportive preventive policy.

Breast cancer is the major mortality cause of women worldwide. In the course of management of breast cancer, the identification of a biomarker is important in enhancing our knowledge on cancer pathology, predicting the response to treatment, and selecting the patients who are more favorable to receive certain treatments. These biomarkers have a prognostic value. In addition to traditional breast cancer prognosis factors such as the tumor size and grade, the axillary lymph node micrometastasis, and biomarkers such as HER2/neu, newly discovered biomarkers have been discovered. Some of these factors are genetic signature in tissue or in peripheral blood. Lipid profil, a simple and accessible biological examination, has been a novel path on the prediction of breast cancer risk of occurrence and recurrence in many studies. The main goal of our review is to evaluate lipid profile and breast cancer risk with an emphasis on the prognosis value of lipid profiles in breast cancer patient management.

Splenic rupture during pregnancy is a rare and can frequently be a misdiagnosed pathology. This rupture is associated with a high maternal and fetal mortality rate. A 26 years old Moroccan woman para II gravida II presented at the third stage of pregnancy with acute onset of severe abdominal pain. She developed immediately a hypovolemic shock. After both a physical and sonographical exam, it was revealed that it was due to a massive hemoperitoneum. Therefore, an emergent laparotomy and cesarean delivery with abdominal exploration were performed; also, an active bleeding was identified at the splenic hilum consistent with splenic rupture. Through this case report, we want to raise awareness of this surgical emergency that requires immediate recognition because any delay can lead to catastrophic consequences

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Introduction/Background Breast lymphomas are extremely rare malignancies in both genders, especially in men. They can be either primary or secondary. Primary ones are malignant lymphomas that occur in the breast without previously detected lymphomas. Their reported incidence is 0.04% of all breast malignancies.We aimed to discuss the clinical aspect, the anatomopathological characteristic, and the evolution of this rare entity. Methodology We report seven cases of breast lymphomas followed up at Salah Azaiez institute of oncology in Tunis. ResultsThe median age at the diagnosis of breast lymphoma was 49 years. Six patients were female. The mean tumor size was 33 mm. inflammatory breast tumor was noticed in one case, while six patients presented a palpable mass. Breast imaging revealed suspicious lesions classified as BIRADS 5 in all cases. Microbiopsy was performed in all cases. Secondary lymphoma was found in six patients (3 high-grade B cell lymphomas, 3 Hodgkin lymphomas), while primary one was noted in a male breast patient. Neoadjuvant chemotherapy followed by a modified radical mastectomy was performed in one case. 6 patients had chemotherapy. Two of them had 2 years of follow-up with no sign of recurrence. One patient had local recurrence. The rest of patients were lost of followup. Conclusion There is no therapeutic consensus because of the rarity and heterogeneity of primary breast lymphomas. Treatment for breast lymphoma is based upon the overall staging of the lymphoma and generally requires chemotherapy, surgery, and radiation therapy.