Background : Infertility is a universal medical problem, 50% was contributed to male factors. Zinc is an important elements for all living cells and it is one of the most important trace elements in our bodies. Nanoparticles, are mall particles, that have a large surface area if compared to their size, this small size, help them to enter into living cells easily. This makes them an essential participant in all biological interactions and their modern applications. The aim was to evaluate the effects of Zinc and Nano zinc on male gonads histology and function. Methods: A double blind case control study, designed to test the effects of Zinc oxide and Nano zinc oxide on 20 rats that were divided randomly into 4 equal groups. Control, Zinc, Nano zinc, and hybrid (zinc and Nano zinc) group. The dose was 0.11mg/kg. Results: There was significant change in in serum Zinc and testosterone, more in ZnNPs containing groups. While the histological picture of testis ameliorated in zinc arm, but worsen in ZnNPs arm of experiment. These results lead to the Conclusion that Nano zinc though improve S. testosterone, it can damage the testicular tissues in certain doses.
Introduction: Hypericum perforatum consists of several biologically active compounds that may affect cell physiology. Objectives: This study attempted to estimate the effect and safety of a tea that was prepared from H. perforatum on renal histology and function. Materials and Methods: A double-blind controlled experimental trial was conducted on 25 male rats. These animals were divided into four groups. Three of them were labeled as the study groups, and each consisted of seven animals. The fourth group was labeled as the control group consisting of four animals that lived in the same environment and consumed the same food as the other groups. The animals in each study group consumed a prepared tea with a different concentration for each group. The herbal tea of H. perforatum was made as recommended by the local traditional preparation method. Doses of 3, 6, and 9 cc/kg/d were calculated and selected according to the recommendation. Each of these doses was given to each group of the experiment for four weeks mixed with water. Results: A slight increase in blood urea and serum creatinine and a decrease in serum albumin levels were noticed in the experimental groups compared to the control group. In addition, the weight of the kidneys in the study groups was more than the control group. There were microscopical changes in the renal histology that was noticed in the higher doses of H. perforatum tea. Conclusion: Higher doses of H. perforatum tea can induce damage to the renal tissue.
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