The world recently faced a serious pandemic caused by a novel coronavirus (severe acute respiratory syndrome coronavirus 2) discovered on December 21, 2019. Public's knowledge and attitudes toward COVID-19 are likely to influence adherence to preventive practices. This study seeks to determine the COVID-19 related knowledge, attitude and practice of students of Adeleke University, Ede, Nigeria This was a cross-sectional study which was conducted between June 9 and July 5, 2022 among students of Adeleke University in Ede, Osun State Nigeria. Data was collected using a structured self-administered questionnaire. Correct COVID-19 related knowledge score ranged between 0 and 13 with a mean score of 7.11 and standard deviation + 2.6. Bulk (63.1%) of respondents had a high level of COVID-19 related knowledge while 36.9% had low level of COVID-19 related knowledge. Score of COVID-19 attitude ranged between 7 and 35 with a mean score of 24.4 and standard deviation +6.9. Seventy-Two percent of respondents have good COVID-19 related Attitude while 28% had poor COVID-19 related Attitude. Score of COVID-19 Related practice ranged between 0 and 6 with a mean score of 4.1 and standard deviation + 1.37. Most (69.2%) respondents have good COVID-19 related practice while 30.8% had Poor COVID-19 related practice. There is statistically significant difference between Knowledge scores among different age groups (P-value 0.03). Respondents with high of COVID 19 related knowledge are 5 times likely to have good COVID-19 related Attitude Awareness and sensitization efforts therefore should be intensified to close the gap in COVID-19 related knowledge, attitude and practice. This will assist to reduce the spread, morbidity and mortality of COVID-19 and help to mitigate the impact of future Coronavirus pandemics. Key words: COVID-19, Knowledge, Attitude, Practice, Adeleke University
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