Highlights d Agxt is hypermethylated and downregulated in mouse and human steatotic hepatocytes d Detoxification of mitochondrial glyoxylate is insufficient in the fatty liver d Challenge with dietary hydroxyproline leads to higher oxalate in the fatty liver d Rescuing Agxt expression in the fatty liver reduces hepatic oxalate production
Highlights d Agxt is hypermethylated and downregulated in mouse and human steatotic hepatocytes d Detoxification of mitochondrial glyoxylate is insufficient in the fatty liver d Challenge with dietary hydroxyproline leads to higher oxalate in the fatty liver d Rescuing Agxt expression in the fatty liver reduces hepatic oxalate production
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