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Calves develop nasal and salivary neutralizing antibodies against foot-andmouth disease virus after nasal inoculation with live virus. Nasal and salivary antibody was not detected after exposure to inactive virus. Serum antibodies were induced by live and inactive virus given subcutaneously. Passively acquired antibodies were detected as long as 7 months after birth.

Interferon production by leukocytes in culture was investigated in nine severely marasmic infants and 31 well-nourished controls. The production of interferon was induced with Newcastle disease virus and assayed in Vero cells challenged with vesicular stomatitis virus. Marasmic infants produced significantly less interferon than controls. It is suggested that the finding may be the result of a lymphocyte defect induced by malnutrition and could help to explain the increased frequency and severity of viral diseases in this condition.

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SUMMARYReduced yields of poliovirus and foot-and-mouth disease virus are obtained in suspended cell cultures in the presence of rifampicin. The effect of the drug appears to be related to virus replication and not to a toxic effect on the host cells. The inhibition is reversed upon removal of the drug. The replication of both picornaviruses in suspended cultures is affected by actinomycin D, but not by mitomycin C.