Treatment of 2,5-Diphenyl-2,4-dihydro-pyrazol-3-one (1) with 2-Chloro-benzaldehyde (2) in ethanol/sodium hydroxide solution afforded the chalcone derivative (3) which was reacted with malononitrile to afford 6-Amino-4-(2-chloro-phenyl)-1,3-diphenyl-1,4-dihydro-pyrano[2,3-c] pyrazole-5-carbonitrile (4). Compound 4 was reacted with formic acid, acetic anhydride, formamide, thiourea, urea, conc. cold sulfuric acid, D-glucose, p-methoxy benzaldehyde, 4-dimethyl aminobenzaldehyde, benzoyl chloride, triethyl orthoformate to afford a series of pyranopyrazole derivatives (5-15). The formimidic acid ethyl ester 15 was reacted with hydrazine hydrate to afford 4-(2-chlorophenyl)-5-imino-1, 3-diphenyl-1,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-6(5H)-amine ( 16). Compound 16 was then reacted with D-xylose to afford the sugar derivative 17. Also compound 16 was reacted with CS2 to afford 18 in a good yield. Evaluation of the antimicrobial, antioxidant and anticancer Activities of the newly synthesized compounds was performed with a Docking study.
Galactomannan gum isolated from the seeds of sesbania is subjected to chemical modification via phosphorylation. This is conducted via heating moistened blends of the gum with a mixture of orthophosphate salt. Three different phosphate ester derivatives are prepared by changing the reaction time. The %P increases from 0.07 to 0.12 to 0.61 by increasing the reaction time from 30 to 60 to 90 minutes.
Modification of sesbania gum via phosphorylation increases the stability of their pastes to storing. Investigation of the rhelogical properties of these pastes indicate that they are characterised by non-Newtonian pseudoplastic behaviour. As the extent of the reaction increases, i.e. %P, the apparent viscosity of the pastes at a constant rate of shear decreases, while storing does not change the rheological characteristics of the pastes.
Utilization of these derivatives as thickening agents in printing wool fabrics by using acid dyes indicate that phosphate derivatives of sesbania seeds could be used as a thickening agent in printing wool fabrics with acid dyes, where the K/S slightly decreases less than the commercial thickening agent named (Meypro gum) while the overall fastness properties are nearly identical.
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