IntroductionDog bites in humans are a major public health problem. Globally, millions of people are bitten by dogs but most of the fatal cases occur in children. There is paucity of data on dog bite related diseases among Nigerian children. Objectives: to determine the pattern of dog bite injuries and associated health problems among children seen at Ekiti State University Teaching Hospital.MethodsThis is a retrospective study on the clinical data of patients managed for dog bite related injuries between January 2010 and June 2014.ResultsIn all, 84 cases of dog bite injuries were managed constituting 0.89% of the total consultations; six (7.1%) had rabies. Most of the victims were aged 6-12 years (60.7%) and majority (71.4%) was boys. Eighty two percent of the victims presented within 24hrs of the injury. Thirty-six (43%) had WHO grade 3 dog bite injury at presentation and the lower limb was the commonest (57.1%) bite site. Use of herbal preparation was the most common pre-hospital treatment 60%. Although 92.9% received anti-rabies vaccine, only 64.3% of them completed the vaccination schedule. The case fatality rate for dog bite was 7.14%. The six that died all presented late, had no post exposure prophylaxis and died within 24 hours of admission.ConclusionThere is need for public enlightenment on dangers associated with dog bites and also for the government to defray the high cost of post exposure prophylaxis treatment for children.
There is need to address causes of school absenteeism among children with SCA.
Background (TA) n repeat sequence (rs8175347) of UGT1A1 gene promoter polymorphism is associated with serum bilirubin levels and gallstones among different sickle cell anaemia (SCA) populations. There are no data on UGT1A1 polymorphisms and their impact on Nigerian SCA patients. In this study, we determined the distribution of the UGT1A1 (TA) n genotypes among a group of young Nigerian SCA patients and healthy controls. In addition, the influence of UGT1A1 (TA) n genotypes on the laboratory and clinical events among the patients was determined. Methods The distribution of the UGT1A1 (TA) n genotypes among 101 young Nigerian SCA patients and 64 normal appropriate controls were determined and studied. The UGT1A1 (TA) n genotypes were further classified into subgroups and used to differentiate the clinical events and laboratory parameters of the patients. Results Four (TA) n alleles:(TA)5, 6, 7, and 8 were found. These were associated with 10 genotypes: TA5/5, 5/6, 5/7, 5/8, 6/6, 6/7, 6/8, 7/7, 7/8, 8/8. The normal (wild-type)-(TA) 6/6), low- (TA) 7/7, 7/8, 8/8), intermediate- (TA) 5/7, 5/8, 6/7, 6/8), and high-activity (TA) 5/5, 5/6,) genotypes were found in 24.8, 24.8, 41.5, and 8.9% patients and 20.3, 15.6, 61, and 3.1% controls respectively. The general genotype distribution of the patients and control group were not significantly different. There were significant differences in serum bilirubin and lactate dehydrogenase (LDH) of the patients when differentiated by the UGT1A1 (TA) n genotypes (p<0.05). Asymptomatic gallstones were found in 5.9% of patients and were significantly of the low-activity genotypes sub-group 5 (20%) vs 1(1.3%) p = 0.0033. Although, bilirubin and fetal hemoglobin (HbF) of patients with gallstones were significantly different from those without gallstone, only the serum bilirubin was associated with UGT1A1 (TA) n genotypes on multivariate analysis (p < 0.0001). Conclusion This study highlights the contribution of UGT1A1 polymorphisms, a non-globin genetic factor, to the laboratory and clinical manifestations of young Nigerian SCA patients for the first time. It also shows that children with co-inheritance of low UGT1A1 (TA) n affinity genotypes may be at risk of gallstone, hence the need to follow them up.
Introduction: This study assessed the socio-demographic profile, outcomes of treatment and challenges encountered in the management of children admitted for Severe Acute Malnutrition at the Paediatric Unit of a State University Teaching Hospital, Ado-Ekiti, Nigeria. Methods: A retrospective cross-sectional study was conducted. The records of twenty-five children with SAM admitted from March 2013-March 2018 were reviewed. SAM was defined according to the Wellcome Classification based on child’s weight and oedema status. Data on demographic characteristics, presenting symptoms, co-morbid conditions, duration of admission and outcome were extracted. Results: There were 13 (52.0%) males and 12 (48.0%) females. The median age of children with SAM was eight months. Eighteen children (72%) were marasmic, four (16%) had kwashiorkor while three (12%) had marasmic-kwashiorkor. Common presenting symptoms included poor weight gain (59.1%), fever (54.5%) and diarrhoea (36.4%). Majority (84.0%) of the patients had co-morbid conditions which included sepsis (66.7%), anaemia (37.5%), hypoglycaemia (16.7%) and hypothermia (16.7%). Twenty-one (84.0%) children were fully vaccinated for age, two (8.0%) had partial vaccination while two (8.0%) were never vaccinated. Only two (8.0%) had exclusive breastfeeding, 19 (76.0%) had mixed feeding from birth. Majority (60%) of the children had one or more social challenges such as teenage parents and financial constraints. Mean duration of admission was 4.56 days. Twelve (48.0%) left against medical advice, nine (36.0%) were discharged, one (4.0%) was referred to another tertiary facility and three (12.0%) deaths were recorded. Conclusions: Many of the children admitted for SAM in our study had social problems and almost half of them left the hospital against medical advice. Besides health problem, social factors may play more role in SAM.
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