Background: Pulmonary arterial hypertension (PAH) is a severe and progressive disease of pulmonary arterioles. This pathology is characterized by elevation of the pulmonary vascular resistance and pulmonary arterial pressure, leading to right heart failure and death. Studies have demonstrated that resveratrol possesses a protective effect in the mechanisms related to the genesis of the PAH-induced by different models. Objective: This study aimed to investigate the dose-related effects of resveratrol in different models of pulmonary arterial hypertension. Methods: To identify eligible papers, we performed a systematic literature search on Scielo, PubMed, and Scholar Google. The research was limited to articles written in English in the last 10 years. We use the following descriptors to search: Pulmonary Arterial Hypertension and Resveratrol, OR Resveratrol, and Animal models of Pulmonary Arterial Hypertension, OR Resveratrol, and in vitro models of Pulmonary Arterial Hypertension. Results: 1724 studies were identified through the descriptors employed, fifty-five studies with different models of pulmonary arterial hypertension were selected for the full review, forty-four were excluded after application of exclusion and inclusion criteria, totalizing eleven studies included in this systematic review. Conclusion: The results showed that resveratrol, at low and high doses, protects in a dose-dependent manner against the development of PAH induced through monocrotaline, normoxia and hypoxia models. In addition to having chemopreventive, anti-inflammatory, antioxidant and antiproliferative properties. In the case of PAH-related myocardial injury, resveratrol protects cells from apoptosis, thus working as an antiapoptotic agent.

Fundamento: O interesse pela hipertensão em crianças e adolescentes aumentou desde a atualização do sistema de classificação da pressão arterial para comparar com o sistema de classificação dos adultos, alterando a terminologia de "normal alta" para "pré-hipertensão". Objetivo: O objetivo deste estudo foi analisar a associação da modulação autonômica cardíaca com os níveis pressóricos dos adolescentes. Métodos: 203 adolescentes foram agrupados de acordo com a pressão arterial sistólica (PAS) e a pressão arterial diastólica (PAD). Um grupo foi caracterizado como pré-hipertensão, e o outro como normotenso. Foram coletadas características antropométricas, cardiovasculares e de qualidade do sono. Inicialmente, os dados foram submetidos ao teste de normalidade Kolmogorov-Smirnov. As variáveis quantitativas contínuas foram analisadas por meio do teste T de Student não pareado. Para análise das variáveis categóricas, foi utilizado o teste qui-quadrado. Um modelo de regressão logística foi realizado. O nível de significância estabelecido foi p<0,05. Os dados foram expressos como média ± desvio padrão e intervalo de confiança. O software R foi utilizado para análise dos dados. O tamanho do efeito foi calculado com a fórmula de Cohen. Resultados: O grupo pré-hipertensão apresentou aumento da entropia de Shannon e diminuição da variância total. Além disso, no modelo de regressão logística, os adolescentes deste grupo tiveram 1,03 mais chances de ter a entropia de Shannon afetada quando a PAS foi ajustada ao gênero, maturação sexual, tempo escolar, idade, circunferência da cintura e qualidade do sono. Conclusão: Nossos dados mostram que a modulação autonômica pode desempenhar um papel importante no desenvolvimento da pressão arterial elevada em adolescentes ao controlar fatores como tempo escolar e qualidade do sono.

The main risk factors for the pathogenesis of DM are related to family history and lifestyle, such as impaired fasting blood glucose, reduced glucose tolerance, gestational diabetes, birth weight greater than 4 kg, sedentary lifestyle, dyslipidemia (triglycerides 360

The aim of the present study was to evaluate the effect of an exercise session prescribed by the Sworkit ® Personal Trainer application on hemodynamic and autonomic responses. Methods: The sample consisted of 11 men classified as sedentary according to IPAQ. The exercises were randomly selected by the app Sworkit ® Personal Trainer, using the pre-built program "Light Warm-Up Cardio" (see supplementary material). Heart rate and perceived exertion data were collected every minute during an exercise session. Blood pressure and heart rate variability were measured Pre, Post, 30 min, 12h, 24 h, and 48h after exercise. Heart rate and rate of perceived exertion were collected during the 30 minutes exercise. Results: Hemodynamic responses showed differences in heart rate and systolic blood pressure: Post, 12 h and 24 h compared to Pre. We also found significant statistical differences in the heart rate variability indexes when comparing Post, 30min to 48h versus Pre, indicating modifications in the autonomic modulation post-exercise. The perceived exertions scale remained between 13-14 during the exercise. Heart rate was 149 ± 5.26 (80 ± 5% of HRmax) during the 30min exercise, indicating a moderate to vigorous intensity. Conclusion: We concluded that a single exercise session guided by the Sworkit® Personal Trainer application could generate autonomic changes in up to 12 hours, presenting a moderate to vigorous intensity in 30 minutes of exercise for sedentary men.

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