A tert-butyl hydroperoxide (TBHP)-mediated coupling of sulfonylhydrazides with thiols catalyzed by CuBr to afford thiosulfonates via a radical process is described.
Air oxidative radical hydroxysulfurization of styrenes initiated by 0.5 mol % of tert-butyl hydroperoxide with arylthiols is described, and a new type of difunctionalization of alkenes was achieved.
A new visible light-mediated photocatalytic decarboxylative oxyphosphorylation of cinnamic acids with diarylphosphine oxides is described. This reaction is performed under mild conditions to afford the corresponding β-ketophosphine oxides.
A double-functionalization reaction of alkenes through Mn(OAc)-mediated phosphinoyl radical addition followed by CuCN-catalyzed cyanation is introduced. This one-pot reaction is performed under mild conditions to afford vicinal cyanophosphinoylation products.
A mild and selective radical nitration/ nitrosation of indoles with NaNO 2 using K 2 S 2 O 8 as oxidant is developed. Free (NH)-indoles and Nmethyl indoles furnished 3-nitro-and 3-nitrosoindoles respectively, in good yields. Contrary to existing protocols, pyrrole selectively afforded 3nitropyrrole. Mechanistic studies showed that the reaction proceeded via an initial formation of nitroso/oxime intermediate, which is further oxidized to the corresponding 3-nitroindole depending on the substitution on the indole N-atom. Furthermore, synthetic transformations were carried out on the synthesized products towards accessing other valuable compounds.
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