Pada penelitian ini telah dilakukan biosintesis ZnO nanopartikel dan kitosan-ZnO nanopartikel sebagai antibakteri Escherichia coli. Tujuan dari penelitian ini adalah modifikasi dan karakterisasi kitosan dengan ZnO nanopartikel dan aplikasinya sebagai antibakteri Escherichia coli. Karakterisasi kitosan-ZnO nanopartikel dilakukan dengan menggunakan spektrofotomer FTIR dan difraksi sinar X (XRD). Difraksi sinar X (XRD) digunakan untuk karakterisasi ZnO nanopartikel. ZnO nanopartikel disintesis melalui reaksi antara ekstrak air daun jambu biji (Psidium guajava L) dengan seng asetat dihidrat. Kitosan-ZnO nanopartikel disintesis melalui reaksi antara kitosan dan ZnO nanopartikel. Metode diffusi agar digunakan untuk meneliti kitosan-ZnO nanopartikel sebagai antibakteri. Hasil penelitian menunjukan bahwa bilangan gelombang pada spektra FTIR kitosan-ZnO nanopartikel muncul pada 3427 cm−1. Ukuran kristal ZnO nanopartikel adalah 16,54 nm. Rata-rata zona inhibisi dari kitosan-ZnO nanopartikel pada konsentrasi 10.000, 5.000 dan 2.500 mg/L berturut-turut adalah 30,57 ± 0,87; 25,97 ± 1,42; dan 23,10 ± 1,61 mm. Semakin tinggi konsentrasi nanopartikel kitosan-ZnO, maka semakin besar pula zona hambatnya.
Background: Pineapples are empirically used by the society to treat gout, and to scientifically prove it, the research was conducted to examine the anti-hyperuricemic effects of the extract of pineapples (Ananas comics (L) Merr) in white rats induced by potassium oxonate and chicken liver juice. Method: This research was an experimental study with a complete randomized design. Animals were divided into 5 groups: negative control group (1% tween 80), positive group (27 mg/kgBW allopurinol), and group III, IV, V given pineapple extract at doses of 125, 250, and 500 mg/kgBW, respectively. Uric acid levels were measured on days 0, 7, 14, and 21. Results: After the treatment using pineapple extract given for 21 days, the mean percentages of decrease in uric acid levels at doses of 125, 250, and 500 mg/kgBW were 18.61%, 27.49%, and 34.27%, respectively, and the positive control had an average of 38.16%. Conclusion:The findings indicated that the three doses could reduce the uric acid levels in hyperuricemic rats. The optimal dose of pineapple extract that could decrease the uric acid levels was the dose of 500 mg/kgBW because it was equal to allopurinol with a significance value of 0.497.
Background: Herbal juice with the composition of rosella flower, garlic, red ginger, dan lime extract, apple cider vinegar andhoney has been proven to be effective as an anti-hypercholesterolemia and has a high level of safety through acute and sub chronic toxicity tests that have been carried out. To be marketed, it is also necessary to know how long this herbal juice formula preserve its antihyperlipidemic effect during the storage process. Objective: This study was aimed to examine the effectiveness of herbal juice stored for 50 days and 100 days in PTU-induced rats and high-fat diet. Methods: This test used 6 groups of animals consists of group I (Na CMC 0.5%/negative control), group II (fresh herbal juice), group III (herbal juice stored 50 days at room temperature), group IV (herbal juice stored for 50 days at cold temperatures), group V (herbal juice stored for 100 days at room temperature), and group VI (herbal juice stored for 100 days at cold temperatures). The dosage of the test preparation was 5.4 ml/kg given once a day for 10 days. Induction was carried out using PTU ad libitum and high-fat diet twice a day for 10 days. Measurement of serum total cholesterol levels was carried out on day 0 and 11 using the CHOD-PAP method. Results: Groups II and IV could reduce cholesterol significantly compared to the negative control group (p<0.05), while the other groups could increase blood cholesterol level. Conclusion: Herbal juice showed effectiveness as anti-hypercholesterolemia in male white rats after being stored for 50 days and 100 days. Shelf life and temperature do not reduce its activity. Keywords:anti-hypercholesterolemia, herbal juice, shelf life, temperature
Abstrak: Kegiatan pengabdian ini bertujuan meningkatkan pelayanan kesehatan oleh mitra kepada masyarakat yang kurang mampu (kaum dhuafa). Mitra yang dipilih adalah sebuah lembaga yang sangat memperhatikan kondisi masyarakat yang miskin (kaum dhuafa), Layanan Kesehatan Cuma-Cuma ini sebuah lembaga nirlaba yang merupakan salah satu unit dari Dompet Dhuafa Palembang. Staf dan karyawan di LKC berjumlah 15 orang, dan hampir semuanya belum memahami pentingnya penggunaan inverter sebagai penghemat daya di klinik LKC. Permasalahan di klinik LKC DD Sumsel adalah belum memiliki peralatan penghemat daya berupa inverter berbasis solar sel yang aman terhadap lingkungan, sedangkan perlatan kesehatan di LKC banyak yang menggunakan listrik. Berdasarkan kondisi tersebut tim pengabdian berinisiatif mengadakan sosialisasi penggunaan inverter sebagai penghemat daya yang benar dan tepat, serta sosialisasi pemeliharaan instalasi listrik yang benar. Setelah sosialisasi terjadi peningkatan pemahaman pemakaian peralatan inverter sebesar 75%, dari 25%, sehingga terjadi peningkatan kualitas pelayanan kesehatan.Abstract: This service activity aims to improve health services by partners to disadvantaged communities (the poor). The partner chosen is an institution that is very concerned about the conditions of the poor (poor), Free Medical Services is a non-profit organization which is a unit of the Dompet Dhuafa Palembang. The staff and employees at LKC are 15 people, and almost all of them do not yet understand the importance of using an inverter as a power saver at LKC clinics. The problem at the LKC DD Sumsel clinic is that it does not yet have power-saving equipment in the form of solar cell-based inverters that are safe for the environment, while many health equipment in LKC uses electricity. Based on these conditions the dedication team took the initiative to conduct socialization of the use of inverters as a true and right power saver, as well as a socialization of the maintenance of the correct electrical installations. After the socialization, there was an increase in understanding of the use of inverter equipment by 75%, from 25%, resulting in an increase in the quality of health services.
Background: Previously, the activity test of the combination herbal juice of garlic, rosella flower, red ginger, lime, apple cider vinegar, and honey, combined herbal juice can lower blood sugar [1] and can reduce total cholesterol levels [11]. In the use of traditional medicine and its effectiveness, its safety must also be proven before herbal juices are circulated in the community Objective: This study was to determine the subacute hepatotoxic effect of the combination herbal juice Method: This research is an experimental study using 24 rats divided into four groups. Namely, the control group was given distilled water, and the group was given the combination herbal juice at a dose of 28, 14, and 7 mg/kg BW/day for 28 days. The measurement parameters were the increased activity of SGOT and SGPT and histopathological features of liver cells. The data were statistically analyzed with one-way ANOVA analysis Results: The administration of combination herbal juice for 28 days at a dose of 28, 14, and 7 mg/kg BW/day did not increase SGOT activity but caused a significant decrease in SGPT levels, namely by 20.34%, 19.39%, and 15.30%. From the histopathological picture of liver cells, at a dose of 28 mg/kg BW/day, there was no histopathological damage to liver cells Conclusion: Subacute administration of combined herbal juice did not cause hepatotoxicity in Wistar male white rats Keywords: Combination herbal juice, subacute toxicity, histopathology, SGOT, and SGPT
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