Artigo / ArticleEfeito da bomba de infusão de soluções sobre o grau de hemólise em concentrados de hemácias
Effect of the infusion pumps of solutions on the degree of hemolysis
Introduction and objective
In this study, we evaluated the influence of the transcript type on hematological and clinical parameters, as well as the event-free survival of 50 patients in the Chronic myeloid leukemia chronic phase.
Methods
We reviewed the medical records of 55 patients with Chronic myeloid leukemia. The eligibility criteria were based on the availability of hematological and clinical baseline data in the medical records. Data on
BCR-ABL
transcripts were obtained from medical records.
Results
Eighteen patients (36%) had the
b2a2
transcript, 24 (48%) had
b3a2
and 8 (16%) had
b2a2/b3a2
. The median platelet count for transcripts
b2a2
,
b3a2
and
b2a2/b3a2
was 320.65 × 10
3
/L, 396 × 10
3
/L, and 327.05 × 10
3
/L, respectively (
p
= 0.896). We could not find any differences in relation to the other hematological parameters, when compared to the transcript type. Comparison between spleen and liver size and type of transcript did not differ inside the groups (
p
= 0.395 and
p
= 0.647, respectively) and the association between risk scores and transcript type did not show statistical significance (
p
> 0.05). The 21-month probability for event-free survival was 21%, 48% and 66% for the transcripts
b2a2
,
b3a2
and
b2a2/b3a2
respectively (
p
= 0.226)
Conclusion
We conclude that the expression
BCR-ABL
transcripts have no influence on hematological, clinical and event-free survival parameters of patients in the Chronic myeloid leukemia chronic phase.
Background: Chronic myeloid leukemia is a neoplasm characterized by clonal expansion of hematopoietic progenitor cells resulting from the (9:22)(q34,11) translocation. The tyrosine kinase abl fusion protein,the initial leukemogenic event in chronic myeloid leukemia, is constitutively activated thus inducing the production of reactive oxygen species. Of particular relevance is the fact that an increase in reactive oxygen species can facilitate genomic instability and may contribute to disease progression. Objetive: To evaluate oxidative stress by determining the levels of malondialdehyde and nitrite in chronic myeloid leukemia patients under treatment with 1st and 2nd generation tyrosine kinase inhibitors monitored at a referral hospital in Fortaleza, Ceará. Methods: A cross-sectional study was performed of 64 male and female adults. Patients were stratified according to treatment. The levels of malondialdehyde and nitrite were determined by spectrophotometry. Statistical differences between groups were observed using the Student t-test and Fisher's exact test. The results are expressed as mean ± standard error of mean. The significance level was set for a p-value < 0.05 in all analyses. Results: The results show significantly higher mean concentrations of nitrite and malondialdehyde in chronic myeloid leukemia patients using second-generation tyrosine kinase inhibitors compared to patients on imatinib. Conclusion: It follows that chronic myeloid leukemia patients present higher oxidative activity and that the increases in oxidative damage markers can indicate resistance to 1st generation tyrosine kinase inhibitors.
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