Determining that miRNAs play a role in breast cancer pathogenesis suggests that it may be useful in the diagnosis and treatment of breast cancer. In this study, 39 patients with invasive breast cancer were diagnosed with serum levels of 20 miRNAs(miR-105, miR-21, miR-141, miR-200a, miR-200b, miR-200c, miR-203, miR-210, miR-375, miR-34a, miR-133a, miR-155, miR-139-5p, miR-143, miR-145, miR-365, miR-299-5p, miR-411, miR-452, miR-17) were analyzed during diagnosis and after treatment. In the analysis results, it is detected that serum levels of miR-200c(p=0.030), miR-375(p=0.045), miR-34a(p=0.042) were significantly higher in the local advanced/metastatic group. Serum level of miR-141(p=0.062) was lower in patients with positive lymph node involvement, whereas miR-133a(p=0.037) levels were higher in the same patient group. MiR-105(p=0.015), miR-203(p=0.015), miR-375(p=0.033), miR-145(p=0.025) serum levels were significantly higher in the progesterone receptor negative group, likewise miR-105(p=0.053) levels were high in the estrogen receptor negative patient group. The high levels of miR-375 and miR-133a were noticeable in human epidermal growth factor receptor-2 positive patients(p=0.037 and p=0.014, respectively). MiR-143(p=0.009) and miR-145(p=0.017) levels were observed to be higher in the patient group with a ki-67 index>20%. It was found that 2 miRNAs(miR-133a(p=0.018) and miR-139-5p(p=0.004)) were significantly higher in patients in the luminal B group, which were separated by molecular subgroups. Nine of miRNAs that evaluated(miR-105(p=0.0001), miR-21(p=0.001), miR-141(p=0.041), miR-200a(p=0.003), miR-200b(p=0.0001), miR-200c(p=0.0001), miR-203(p=0.0001), miR-34a(p=0.0001), miR-452(p=0.018)) significantly increased after treatment and 5 of the miRNAs(miR-155(p=0.0001), miR-143(p=0.0001), miR-145(p=0.0001), miR-365(p=0.0001), miR-299-5p(p=0.0001)) were significantly reduced after treatment. We think that miRNAs may help in evaluating the follow-up and prognosis of invasive breast cancer.

Aim: Dementia, sarcopenia, and urinary incontinence (UI) are common geriatric syndromes. UI is a condition that affects the quality of life, results in social isolation, causes falls and, causes morbidity and mortality due to falls. UI also increases caregiver burnout and the burden of care in dementia patients. Continence requires an intact genito-urinary system, peripheral and central nervous system, and cognitive health. In addition, the importance of the pelvic floor muscles from the striated muscle group and the skeletal system in continence cannot be ignored. In the light of these facts, we aimed to evaluate the relationship between UI and sarcopenia in patients with dementia. Materials and Method: Dementia patients with sarcopenia who applied to the DEU Geriatrics unit between January 2015 and December 2021 were included. Patients with CDR 3 dementia and those with acute problems were excluded. Patients were grouped according to their UI status and evaluated for sarcopenia using the EWGSOP-2 criteria. Results: According to the presence of UI, no significant difference was found in demographic and laboratory findings between groups. The frequency of anti-parkinsonian drug usage and depression was more common in the UI group. While, the frequency of probable sarcopenia, severe sarcopenia, slow gait speed, and frailty was higher in the UI group; Barthel's score was lower (p

Purpose Dysautonomia is one of the supportive clinical features in dementia with Lewy bodies (DLB). This study aimed to investigate the prevalence of postural and postprandial blood pressure changes as a sign of dysautonomia in DLB patients. Methods The study group comprised 125 patients with DLB (76 females; mean age 78.4 ± 7.1 years) and 126 controls (89 females; mean age 74.5 ± 6.8 years). Postprandial blood pressure changes were assessed by ambulatory 24-hour blood pressure monitorization. Postural blood pressure changes were assessed via the head-up tilt table test. Results The frequency of postprandial hypotension (PPH), orthostatic hypotension (OH), and delayed OH was higher in patients with DLB compared to controls (89.4% vs 50.8%; p < 0.001, 45.5% vs 28.6%; p = 0.006, and 13.3% vs 5.6%; p = 0.045, respectively); whereas the frequency of supine hypertension (HT), and orthostatic hypertension (OHT) was similar. However, supine HT in non-hypertensive participants was higher in DLB patients than in controls (n = 45, 48.9% vs n = 37, 27%; p = 0.043). PPH and OH were independently associated with DLB (odds ratio [OR]:10.52 confidence interval [CI]%95 3.11–35.61; p < 0.00, and OR:1.96 CI%95 1.05–3.69; p = 0.035, respectively) after adjustment for age, the number of drugs, anti-psychotics, antiparkinsonian drugs, angiotensin receptor blockers, and beta blockers. Conclusion The study demonstrated that PPH was the most common type of dysautonomia, followed by OH and supine HT in older patients with DLB Given the potential complications of postural blood pressure changes and PPH in such patients, autonomic dysfunction should be evaluated in the follow-up of DLB.

Amaç: Depresyon, yaşlılarda morbidite ve mortaliteye sebep olan geriatrik sendromlardan biridir. Depresyonun erken tanı ve tedavisi bireyin yaşam kalitesi için önemlidir. D vitamini depresyon patofizyolojisinde rol oynayan bir nörosteroid hormondur ve eksikliği yaşlılarda sık görülmektedir. Bu çalışmanın amacı, yaşlılarda sık görülen geriatrik sendromlardan biri olan depresyonun D vitamini ile ilişkisini değerlendirmektir.Gereç ve Yöntemler: Çalışmaya 60 yaş ve üzeri 392 hasta alındı. Çalışmamız kesitsel retrospektif olarak dizayn edildi. Katılımcıların sosyodemografik verileri, komorbiditeleri, laboratuvar parametreleri, geriatrik depresyon ölçeği puanları, yürüme ve denge ölçeklerini içeren Ayrıntılı Geriatrik Değerlendirme verileri hasta takip dosyalarından incelenerek değerlendirildi. Elde edilen sonuçlarla prevelans analizi yapıldı.Bulgular: D vitamini değerleri, depresyon tanısı olan grupta, depresyon tanısı olmayan gruptan anlamlı olarak düşüktü (p&lt;0,01). Her iki grup yaş açısından benzerlik göstermekteydi. Depresyon tanısı alanlarda kadın cinsiyet oranı daha fazlaydı (p&lt;0,01). Depresyon; düşme, malnutrisyon, kadın cinsiyet, düşük eğitim durumu ve ilaç sayısı ile ilişkili bulundu (p&lt;0,001). Yaş ve cinsiyet faktörü düzeltildiğinde, depresyonun D vitamini ile ilişkisi ortadan kalktı.Sonuç: Depresyon ve D vitamini arasında anlamlı bir ilişki bulunmaktadır. Depresyonu olan yaşlı bireylerde D vitamini değerlerini normalize etmek, oluşabilecek morbidite ve mortaliteyi önlemek için yapılan müdahalelerden biri olabilir. Bu konuda yapılacak destekleyici çalışmalara ihtiyaç vardır.