A characteristic clinical feature of COVID-19 is the frequent incidence of microvascular thrombosis. In fact, COVID-19 autopsy reports have shown widespread thrombotic microangiopathy characterized by extensive diffuse microthrombi within peripheral capillaries and arterioles in lungs, hearts, and other organs, resulting in multiorgan failure. However, the underlying process of COVID-19-associated microvascular thrombosis remains elusive due to the lack of tools to statistically examine platelet aggregation (i.e., the initiation of microthrombus formation) in detail. Here we report the landscape of circulating platelet aggregates in COVID-19 obtained by massive single-cell image-based profiling and temporal monitoring of the blood of COVID-19 patients (n = 110). Surprisingly, our analysis of the big image data shows the anomalous presence of excessive platelet aggregates in nearly 90% of all COVID-19 patients. Furthermore, results indicate strong links between the concentration of platelet aggregates and the severity, mortality, respiratory condition, and vascular endothelial dysfunction level of COVID-19 patients.

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We present a new method for estimating signal model parameters using the Cumulative Distribution Transform (CDT). Our approach minimizes the Wasserstein distance between measured and model signals. We derive some useful properties of the CDT and show that the resulting estimation problem, while nonlinear in the original signal domain, becomes a linear least squares problem in the transform domain. Furthermore, we discuss the properties of the estimator in the presence of noise and present a novel approach for mitigating the impact of the noise on the estimates. The proposed estimation approach is evaluated by applying it to a source localization problem and comparing its performance against traditional approaches.