das clinicas, EWSP, Sio Paulo, Brazil. A close relationship exists between the presence of a watery and acidic diarrhea and the developmt of wtnbolic acidosis in AGI infants.With ti= cbjective to identify psiblc mhanisms of acidosis, 12 malnourished infants, 2 to 17 tmnths old were studied during 3 to 4 days, by the NAB tecMgue, divided in : ~roup 1 -infants with diarrhea, glucose in stools, and acidosis; Group 2 -infants who tolerated fanrula feedings wll and free of acidosis. !&dcgenous ayid produdion (AP) was significantly higher ingroup 1: 3.69 -1.92 vs 0.45 + 1.70 mEq/kg/day (p <.002). Urinary excretion of sulfate was similar m both groups and organic acids (OA) *fire higher in group 1 (p < .05).Absorbed wdetermined anions (UA) were significantly different between the groups, positive in group 2, representing base gained : 1.65 2 1.80 -/kg and negativ? in group 1 , representing p r d u d and gained acid: -022 -1.85 -/kg (p < .05). Urinary net acid excretion (NAE) was similar in both groups, obseming group 1 w k had inappropriated high urinary pIl and bicarbonaturia. We c~cluded that the wtnbolic acidosis was conditioned largely by the averproduction of intestinal OA as well as urinary excretion of PD as salts. Irrpahnt in N U was the factor respcolsible far maintaining systemic acidosis in group 1.Between an+ and JULY i988, 14 chil&en Gi;ith HUS, 28 m and 12 C were investigated. Mean age of HUS was, 11.9 mths(3 -36) and of C, 7.5 m t h s (3-15) . In bth groups sex distribution was 50%.ptcdmml illness i n HUS was ahKactt?rized by diarrhea in 100%, bloody stmls in 85.7% and upperrespiratory tract symptaw in 21.4%.Laboratory data in H I 6 and C respectively were: hemtocsit 22% (13-29) and 34 (28-41) ; leukocytes, 23,170 (8,800-91,000) and 10,700 (7,800-14,300). Platelet cnunt, 92,000 (10,000-200,000 ) and 287,000 (170,000-650,000); blcad urea, 16-% (40-290) and 22 (10-61); senon neatinine, 3.-% (0.8-7.8) and 0.54 (0.45 -0.81). In HUS red blood cell transfusion and peritonealdialysis was respectively required in 78.6% and 42.9% of the oases.First sanples were obtained in HUS at mean of 9.6 days (4-27) and in C at 5.8 days (2-16) after the onset of acute diarrhea. 42.8% of HUS and none of C had reveived previous antibiotictreaL m t . President-Elect Carlos CaballeroParaguay SHIGA-LIKE TOXIN (SLT) ASSOCIATED DIARRHEA AND HEMOLYTIC UREMIC SYNDROME (IiUS) IN ARGEN m e n t i n a . Universitv of Texas Medical School, ~ouston , T G X~~, USA.We conducted a prospective study to determine the frequency of SLT-related HUS and SLT-related diarrhea in Argentinian children. Fecal toxin measuredina OH) Hela cell system was detected in 10/31 (32%) HUS patients, in 7/31 (22.6%) age -season matched children with diarrhea (CD) and in 0/19 (0%) healthy children (p<0.025). Neutralization with specific antiserashow ed that in 5 HUS patients and in 4 CD only SLT-I was present and in 5 HUS and 3 CD SLT-I and SLT-I1 were found. DNA hybridization was used to screen 555 E. coli strains isolated from these patients forSLT-I and -SLT-11. ...
titers. The 3 patients with high titers and a decrease in growth solution was observed; however, the hemin showed a lower abvelocity all had an isolated hereditary growth hormone deficiency. sorption value (P < 0.01) in aqueous solution. It can be concludedIn conclusion, most patients with negative, low, or medium that fortification of whole milk with hemoglobin preparations is anti-HGH antibody titers grow adequately. The presence of high feasible. The addition of hemoglobin preparations to milk appears level titers inhibited the growth response to HGH administration. to be an excellent combination because of the organoleptic characteristics and high bioavailability of iron. We have found that marasmic malnutrition in rats permanently decreases uterine cell number. On the other hand, a decrease of total plasma estrogen levels in mothers of small for gestational age newborns has been demonstrated. We have found, also, decreased levels of sex hormone binding globulin in these mothers, suggesting lower levels of free plasma estrogens. As an index of hormone action upon the target cells, we studied uterine estradiol receptors of early malnourished rats. Malnutrition was induced in rats by increasing litter size to 18 pups per dam from birth until weaning. These offspring received a 22% protein diet from days 21-90 of life. Control dams nursed 6 pups, which were fed the normal diet after weaning; all animals were killed at 90 days. x respectively, P < 0.025). These results show that the number of estradiol receptors in the uterus of rats malnourished early in life is decreased. This is more evidence that early malnutrition produces damage in the uterus of the rat. In the past, milk has been fortified with inorganic iron compounds. The bioavailability of these compounds for absorption is altered according to the properties of the vehicle. The purpose of this work was to study the possibility of fortifying whole milk with organic iron obtained from fresh bovine red blood cells. The organic iron preparations used in this study were: 1) hemoglobin with stroma, 2) hemoglobin without stroma, 3) hemin. These compounds are soluble in milk and water (with the exception of hemin), do not alter the flavor of the milk, and give the milk a chocolate color. The absomtion of these ~r e~a r a t i o n s was studied pathology associated with a catecholamine increase. Of the sympathoblastoma patients, 30 were studied before any treatment (group I) and 26 after treatment (group 11). In group I, all but 1 yielded positive tests: 28 had increased VMA and 2 had normal VMA. From this group, 16 patients were followed during treatment: 11 continued with positive tests and increased VMA excretions and 5 converted to negative tests and normal VMA. In group 11, 19 were negative, 4 were intermediate, and 3, all with normal VMA, were positive. Only one patient persisted with positive tests in the subsequent evaluations. High Affinity Estrogen Receptors in Uterus of Bioavailability of Heme-Iron Preparations Derived fromIn conclusion, the La Brosse...
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