An extensive study of the relationship of peptic ulcer to adrenal steroid therapy has led to the conclusion that certain corticosteroids are responsible for gastric ulceration, probably as a result of direct effects on the mucosa.
Peptic ulcer was observed radiographically in 31 per cent of patients with rheumatoid arthritis receiving adrenal steroids but in only 9 per cent of patients not treated and 5 per cent of nonrheumatoid controls. Hydrochloric acid and pepsin secretion were not influenced significantly by the administration of corticosteroids.
Un extense studio del relation inter ulcere peptic e therapia adreno‐steroide ha resultate in le conclusion que certe corticosteroides es responsabile pro ulceration gastric, probabilemente in consequentia de effectos directe super le mucosa.
Ulcere peptic esseva observate radio‐graphicamente in 31 pro cento de patientes con arthritis rheumatoide qui recipeva steroides adrenal sed solmente in 9 pro cento de tal patientes qui non recipeva steroides adrenal e in 5 pro cento de non‐rheumatoide subjectos de controlo. Le secretion de acido hydrochloric e de pepsina non esseva influentiate a grados significative per le administration de corticosteroides.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.