Case Report Sister Mary Joseph's nodule (SMJN) is a metastatic umbilical tumor. It is a very rare condition, with a poor prognosis; however, it can be the first sign of intra-abdominal cancer, most commonly an adenocarcinoma metastasis from a gastrointestinal or gynecologic primary malignancy. We report a case of umbilical skin metastasis (or Sister Marie-Joseph's nodule) revealing bilateral ovarian adenocarcinoma in a 61-year-old patient. And through this case we emphasize on the delayed diagnosis associated with this tumor.
The coexistence of Crohn's disease (CD) and Takayasu's disease (TD) does not seem to be accidental and does not seem to modify the natural course of the 2 pathologies. The granulomatous character of the inflammatory infiltrate of the vascular wall appears to be the result of the pro-inflammatory effect of several cytokines, such as TNF and the IL-6, -8, -12 and -18 common to both entities. The literature reports more than 40 cases of Takayasu's disease associated with Crohn's disease. However, the association of these two pathologies with autoimmune thyroiditis has never been described before in the literature. In a case hospitalized in the gastroenterology department of the Mohammed VI University Hospital in Marrakech, of a woman with autoimmune thyroiditis treated by total thyroidectomy and hormone replacement therapy, Crohn's disease and Takayasu's disease for which she was treated by antiTNF treatment and the evolution was marked by a good clinical response.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.