Background: Since 2013, the incidence rate of breast cancer has remained as the first rank among female cancers worldwide. Breast cancer is a heterogeneous disease that has different environmental and genetic risk factors. In recent years, advances in molecular techniques resulted in the inaccurate characterization of molecular markers and therefore improvement of diagnostic and treatment methods. GWA studies play a key role in determining low-penetrance variants that influence the susceptibility of breast cancer. Studies have shown the strong association of two markers, rs10995190 and rs10822013, on chromosome 10q21.2, with breast cancer among different populations. Considering genetic diversity among various populations and the fact that the association of these markers with the risk of developing breast cancer has not been investigated in our population, our study aimed to investigate if these markers are associated with increased risk of breast cancer in the Khorasan province population. Methods: The current study was conducted on 400 women, including 185 breast cancer patients and 215 healthy controls. Genotyping was performed using ARMS_PCR method. Results: There was a significant difference in rs10822013 genotype allele frequencies between patient and control groups (P<05). However, there were no significant differences in genotype and allele frequencies between patient and control group (P=0.41) for rs10995190. Conclusion: Based on the results, rs10822013 may increase the risk of breast cancer in our population, which is in line with the other results in the Asian population. Citation Format: Alireza Pasdar, Abolfazl Nesay, Amir Tajbaksh, Mahdi Rivandi, Fahime Afzal Javan, Atefe Moezzi, Younes Toroghyan, Amirhossein Ghasemi, Hossein Soltanian, Mahta Salehi, Fatemeh Homaei Shandiz. Association of the main variants of the 8q24- rs13281615 and 2q35-rs13387042 with breast cancer risk in Khorasan population [abstract]. In: Proceedings of the AACR Special Conference: Advances in Breast Cancer Research; 2017 Oct 7-10; Hollywood, CA. Philadelphia (PA): AACR; Mol Cancer Res 2018;16(8_Suppl):Abstract nr A11.
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