SARS-CoV2, a single-stranded RNA virus that can cause a wide array of clinical manifestations ranging from mild to severe (respiratory failure). The spread of SARS-CoV2 has now become uncontrollable leading to a pandemic. The infection is usually transmitting through cough droplets and sneeze. The main clinical manifestations of the disease are similar to common respiratory tract infections and may become fatal after the development of symptoms such as severe dyspnea, low PaO2/FiO2 (fraction of inspired oxygen) ratio, and severe decline in blood oxygen saturation. Current diagnostic tools employed at the moment include time-consuming NAAT (nucleic acid amplification test). Recent investigations and researches are aimed at rapid serological testing. Real-time reverse transcription-polymerase chain reaction (rRT- PCR) is the standard method of testing, using respiratory samples obtained by the nasopharyngeal swab. Medications such as darunavir, ribavirin, remdesivir, interferon, and lopinavir/ritonavir combination therapy were used for the management of the infection. Social distancing, use of protective masks, isolation of the infected persons and maintaining personal hygiene helps in the prevention of the disease.
Wegener’s Granulomatosis, also known as granulomatosis with polyangiitis, is a rare multisystem autoimmune disease with an unknown etiology that can affect persons of all ages. In most cases, the condition affects the respiratory tract and the kidneys. The initial symptoms include a runny nose (rhinorrhea), nasal crusting, and nasal blockage or congestion. More significant symptoms include nose bleeds, ulcerations of the nasal mucous membranes with subsequent bacterial infection, sinus discomfort, sinus inflammation, and hoarseness. The patient was presented with symptoms like reddish staining of the eyes, hearing loss, and numerous joint discomfort and swelling of the lower limbs. The antineutrophil cytoplasmic antibody, cytoplasmic (C-ANCA), and human leukocyte antigen- B27 (HLA-B27) were both positive, and renal biopsy revealed necrotizing and crescentic glomerulonephritis. The treatment was initiated with corticosteroids and monoclonal antibodies. The patient responded positively to the therapy, and her health appears to be improving.
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