In this paper, we develop a first principles model that connects respiratory droplet physics with the evolution of a pandemic such as the ongoing Covid-19. The model has two parts. First, we model the growth rate of the infected population based on a reaction mechanism. The advantage of modeling the pandemic using the reaction mechanism is that the rate constants have sound physical interpretation. The infection rate constant is derived using collision rate theory and shown to be a function of the respiratory droplet lifetime. In the second part, we have emulated the respiratory droplets responsible for disease transmission as salt solution droplets and computed their evaporation time, accounting for droplet cooling, heat and mass transfer, and finally, crystallization of the dissolved salt. The model output favourably compares with the experimentally obtained evaporation characteristics of levitated droplets of pure water and salt solution, respectively, ensuring fidelity of the model. The droplet evaporation/desiccation time is, indeed, dependent on ambient temperature and is also a strong function of relative humidity. The multi-scale model thus developed and the firm theoretical underpinning that connects the two scales-macro-scale pandemic dynamics and micro-scale droplet physics-thus could emerge as a powerful tool in elucidating the role of environmental factors on infection spread through respiratory droplets.

Three-quarters of the ocean crust formed at fast-spreading ridges is composed of plutonic rocks whose mineral assemblages, textures and compositions record the history of melt transport and crystallization between the mantle and the seafloor.Despite the significance of these rocks, sampling them in situ is extremely challenging due to the overlying dikes and lavas. This means that our models for

Face masks prevent transmission of infectious respiratory diseases by blocking large droplets and aerosols during exhalation or inhalation. While three-layer masks are generally advised, many commonly available or makeshift masks contain single or double layers. Using carefully designed experiments involving high-speed imaging along with physics-based analysis, we show that high-momentum, large-sized (>250 micrometer) surrogate cough droplets can penetrate single- or double-layer mask material to a significant extent. The penetrated droplets can atomize into numerous much smaller (<100 micrometer) droplets, which could remain airborne for a significant time. The possibility of secondary atomization of high-momentum cough droplets by hydrodynamic focusing and extrusion through the microscale pores in the fibrous network of the single/double-layer mask material needs to be considered in determining mask efficacy. Three-layer masks can effectively block these droplets and thus could be ubiquitously used as a key tool against COVID-19 or similar respiratory diseases.

We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into airborne nuclei’s infectivity and viral load distribution during the COVID-19 pandemic. The salt-water solution containing particles at reported viral loads is acoustically trapped in a contactless environment to emulate the drying, flow, and precipitation dynamics of real airborne droplets. Similar experiments validate observations with the surrogate fluid with samples of human saliva samples from a healthy subject. A unique feature emerges regarding the final crystallite dimension; it is always 20%–30% of the initial droplet diameter for different sizes and ambient conditions. Airborne-precipitates nearly enclose the viral load within its bulk while the substrate precipitates exhibit a high percentage (∼80–90%) of exposed virions (depending on the surface). This work demonstrates the leveraging of an inert nano-colloidal system to gain insights into an equivalent biological system.

pH regulates the transmembrane transport of Cl− ions by bis(iminourea) derivatives.

Identifying the relative importance of the different transmission routes of the SARS-CoV-2 virus is an urgent research priority. To that end, the different transmission routes and their role in determining the evolution of the Covid-19 pandemic are analyzed in this work. The probability of infection caused by inhaling virus-laden droplets (initial ejection diameters between 0.5 µ m and 750 µ m, therefore including both airborne and ballistic droplets) and the corresponding desiccated nuclei that mostly encapsulate the virions post droplet evaporation are individually calculated. At typical, air-conditioned yet quiescent indoor space, for average viral loading, cough droplets of initial diameter between 10 µ m and 50 µ m are found to have the highest infection probability. However, by the time they are inhaled, the diameters reduce to about 1/6th of their initial diameters. While the initially near unity infection probability due to droplets rapidly decays within the first 25 s, the small yet persistent infection probability of desiccated nuclei decays appreciably only by , assuming that the virus sustains equally well within the dried droplet nuclei as in the droplets. Combined with molecular collision theory adapted to calculate the frequency of contact between the susceptible population and the droplet/nuclei cloud, infection rate constants are derived ab initio , leading to a susceptible-exposed-infectious-recovered-deceased model applicable for any respiratory event–vector combination. The viral load, minimum infectious dose, sensitivity of the virus half-life to the phase of its vector, and dilution of the respiratory jet/puff by the entraining air are shown to mechanistically determine specific physical modes of transmission and variation in the basic reproduction number from first-principles calculations.

Synthetic anion transporters have been recognized as one of the potential therapeutic agents for the treatment of diseases including cystic fibrosis, myotonia, and epilepsy that originate due to the malfunctioning of natural Cl ion transport systems. Recent studies showed that the synthetic Cl ion transporters can also disrupt cellular ion-homeostasis and induce apoptosis in cancer cell lines, leading to a revived attention for synthetic Cl ion transporters. Herein, we report the development of conformationally controlled 1,2-diphenylethylenediamine-based bis(thiourea) derivatives as a new class of selective Cl ion carrier. The strong Cl ion binding properties ( K = 3.87-6.66 mM) of the bis(thiourea) derivatives of diamine-based compounds correlate well with their transmembrane anion transport activities (EC = 2.09-4.15 nM). The transport of Cl ions via Cl/NO antiport mechanism was confirmed for the most active molecule. Perturbation of Cl ion homeostasis by this anion carrier induces cell death by promoting the caspase-mediated intrinsic pathway of apoptosis.

We describe a novel class of amphiphiles with squaramide moiety as a phosphate bioisostere. Most synthesized squaramide-based amphiphiles have the favorable physicochemical properties of lipids, such as: formation of stable liposomes or giant unilamellar vesicles in aqueous solution, high phase-transition temperature, low vesicle leakage and phospholipase resistance properties.