Refrigeration and air-conditioning systems become an integral part of modern society. Electricity-driven vapour compression systems have been dominating the heating, ventilation, air conditioning and refrigeration (HVAC&R) industry. The working fluids of these systems often contribute to the environmental issues in the forms of direct and indirection emissions. Pure refrigerants are often limited inmeeting criteria such as efficiency, flammability, toxicity, and compatibility. Meanwhile, refrigerant mixtures offer flexibilities to tune these criteria, This paper will review the status worldwide on technical and policy search for next-generation refrigerants with both low Global Warming Potential (LGWP) and low Life Cycle Climate Performance (LCCP) with particular focus on R410A replacement for unitary A/C & H/P. R32 and the HFO blends offer potential solutionsbut all involve tradeoffs among Global Warming Potential (GWP), efficiency, safety, and cost. With the U.S. mandating new higher regional efficiency standard taking effect January 2015, there is even more pressure in finding a LowGWP refrigerant solution that is affordable and can sustain efficiency and reduce charge requirement. This paper focuses more on R32 as the available data for HFO blends is limited. And Mixing of both R32a and HFO-1234yf in Ac To Study the performance two different next generation refrigerants R32 and Hfo-1234yf.To determine most promising refrigerant blend for air conditioning system test observe, anaylize and compare result obtained with conventional refrigerant. To determine impact of R32 and HFO-1234yf refrigerant as a replacement of R410A
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