Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal condition. Ulcerative colitis and Crohn’s disease are types of inflammatory bowel disease. Over many decades, the disease has been a topic of study, with experts still trying to figure out its cause and pathology. Researchers have established many in vivo animal models, in vitro cell lines, and ex vivo systems to understand its cause ultimately and adequately identify a therapy. However, in vivo animal models cannot be regarded as good models for studying IBD since they cannot completely simulate the disease. Furthermore, because species differences are a crucial subject of concern, in vitro cell lines and ex vivo systems can be employed to recreate the condition properly. In vitro models serve as the starting point for biological and medical research. Ex vivo and in vitro models for replicating gut physiology have been developed. This review aims to present a clear understanding of several in vitro and ex vivo models of IBD and provide insights into their benefits and limits and their value in understanding intestinal physiology.
The present research aimed to study the in vitro radical scavenging activity, anti-ulcer, and analgesic activity of a metal-curcumin complex (MCC) using different models in mice and rats. The antioxidant activity was determined using DPPH free radical scavenging assay, FRAP assay, and ABTS radical cation scavenging assay. MCC showed an effective radical scavenging activity. Trolox was used as a standard in all three assays. Radical scavenging activity was compared with curcumin, showing that MCC was a more effective radical scavenger than curcumin. The antiulcerogenic effect was determined using the ethanol-induced method in Sprague Dawley rats, and it showed that MCC was able to produce gastroprotection at an oral dose of 100 mg/kg body weight (b.w). Further, we have also analyzed the analgesic potential of MCC. Analgesic activity of MCC was recorded using the hot plate method in Swiss albino mice. MCC exhibited analgesic activity at an oral dose of 50 mg/kg b.w. As a result, MCC may be bene cial in treating in ammatory illnesses.
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