Compounds (IIIb) and (IIIc) are potent hypoglycemic agents with activity comparable to the standard drug metformin. -(DAS, N.; VERMA, A.; SHRIVASTAVA, P. K.; SHRIVASTAVA*, S. K.; Indian J.
A family of cationic heavy alkaline earth-metal complexes based on the weakly coordinating tetraphenylborate anion [BPh 4 ] Ϫ provides unique insight into ion association trends within this family of compounds. The compounds were prepared by protonolysis of the respective alkaline earth-metal bis[bis(trimethylsilyl)]amides M[N(SiMe 3 ) 2 ] 2 (thf) 2 (M ϭ Ca, Sr, Ba) with ammonium tetra-903 phenylborates [R 3 NH][BPh 4 ] (R ϭ Me, Et) in various stoichiometric ratios, resulting in the separated ions [M(donor) n ][BPh 4 ] 2 (M ϭ Ca, Sr, Ba; n ϭ number of donors). All compounds but [Ba(hmpa) 6 ][BPh 4 ] 2 (3c) were characterized using single-crystal Xray diffraction, 1 H and 13 C NMR, IR spectroscopy and melting point.coordination chemistry of the complexes. This trend is exacerbated by the weakness of the alkaline earth metalϪligand bond that renders the relatively weak metaldonor interactions structure-determining. Scheme 1. Ion-association modes for alkaline earth-metal compounds.
Benign prostatic hyperplasia (BPH) is the noncancerous growth of the prostate gland resulting due to overproliferation of the stromal and glandular elements of the prostate and is associated with lower urinary tract symptoms. Natural products, containing inherently vast structural diversity than synthetic compounds, have been the major resources of bioactive agents and will continue to play as protagonists for discovering new drugs. Phytotherapeutic products have been used traditionally in developing countries while the use of them as complementary alternative medicine is increasing rapidly in developed countries for the management of BPH. Although mono preparations (single plant only) are available, many industries manufacture combination products (plant extracts) in an attempt to provide enhanced efficacy to improve marketability, and to provide their own "unique" product that can be registered, because these products have no patent protection. The mechanism of action of the phytotherapeutic agents is not clearly understood as many in vitro experimental studies have demonstrated diverse spectrum of mechanisms. The main mechanisms of action that has received the greatest attention are anti-inflammatory, 5α-reductase inhibition, and more recently growth factor alteration. The current review covers all such studies and critiques the efficacy and value of such phytotherapeutic products and preparations available for the management of BPH.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.