An enantioselective dearomatization of isoquinolines has been developed using chiral anion-binding catalysis. This transformation makes use of silyl phosphite as a nucleophile and generates cyclic α-aminophosphonates.
Deconjugated butenolides have emerged as a popular synthon for the enantioselective synthesis of γ-lactones. This review provides a comprehensive overview on the catalytic asymmetric reactions of deconjugated butenolides reported till date.
The first organocatalytic enantioselective direct vinylogous Michael reaction of α,β-unsaturated γ-butyrolactam to nitroolefins is developed using cinchona alkaloids as the catalysts. Both product enantiomers are accessible with moderate to good enantioselectivity.
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