Novel drug delivery systems are now a day is creating a new interest in development of drug deliveries. The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. Transferosomes are capable of transdermal delivery of low as well as high molecular weight drugs. This offers several potential advantages over conventional routes like avoidance of first pass metabolism, predictable and extended duration of activity, minimizing undesirable side effects, utility of short half life drugs, improving physiological and pharmacological response and have been applied to increases the efficiency of the material transfer across the intact skin, by the use of penetration enhancers and non-ionic surfactant vesicles. It is suitable for controlled and targeted drug delivery and it can accommodate drug molecules with wide range of solubility. Due to its high deformability it gives better penetration of intact vesicles. Transferosome possess an infrastructure consisting of hydrophobic and hydrophilic moieties together and as a result can accommodate drug molecules with wide range of solubility. They are biocompatible and biodegradable as they are made from natural phospholipids and have high entrapment efficiency. In this review, we have focused on transferosome with discussions on novel drug delivery systems for targeted delivery of therapeutics and important issues and challenges for future clinical applications.
Keywords: Novel drug delivery systems, Transferosomes, Transdermal drug delivery, Targeted drug delivery
Multiple Mixes have been proposed to have multitudinous uses including their use for improvement of bioavailability or as a dragged medicine delivery system. But the essential insecurity of this system needs to be overcome before they find implicit operation in medicinals. Multiple mixes are frequently stabilized using a combination of hydrophilic and hydrophobic surfactants. The rate of these surfactants is important in achieving stable multiple mixes. The purpose of the study was to prepare a stable multiple conflation containing a skin anti-aging agent and using paraffin oil emulsion. Vitamin C, was incorporated into the inner waterless phase of water- in- oil emulsion- in- water (w/ o/ w) multiple conflation at a attention of 1. Multiple conflation was prepared by two step system. Stability studies were performed at different accelerated conditions, i.e. 8°C (in refrigerator), 25°C (in roaster), 40°C(in roaster), and 40°C at 75 RH (in stability cabin) for 28 days to prognosticate the stability of phrasings. The ideal of this study was to prepare multiple conflation of Ascorbic acid by two step emulsification using different non-ionic surfactants, Tweens and Agar, and estimate for stability, chance medicine ruse. The study concluded that stable multiple conflation with high ruse effectiveness can be prepared by two step emulsification system using agar- agar primary emulsifier and Tween 80 as secondary emulsifier. F2 formulation is the best formulation than the F1 and F3 formulations based on phase separation and other tests.
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